Dalteparin sodium

Dalteparin sodium
Clinical data
Trade names Fragmin
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • AU: C
  • US: B (No risk in non-human studies)
Legal status
Routes of
administration
subcutaneous
Pharmacokinetic data
Bioavailability 81-93%
Biological half-life 3-5 hours subcutaneous; 2.1-2.3 hours IV
Excretion Renal
Identifiers
CAS Number 9041-08-1
ATC code B01AB04
DrugBank DB06779
ChemSpider none
KEGG D03353

Dalteparin is a low molecular weight heparin. It is marketed as Fragmin by Pfizer Inc. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of deep vein thrombosis and pulmonary embolism. It is normally administered by self-injection.

The CLOT study, published in 2003, showed that in patients with malignancy and acute venous thromboembolism, dalteparin was more effective than warfarin in reducing the risk of recurrent embolic events.[1] Dalteparin is not superior to unfractionated heparin in preventing blood clots.[2]

Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.[3]

References

  1. Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M (2003). "Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer". N Engl J Med 349 (2): 146–53. doi:10.1056/NEJMoa025313. PMID 12853587.
  2. The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group (2011). "Dalteparin versus unfractionated heparin in critically ill patients". doi:10.1056/NEJMoa1014475.
  3. Douketis J, Cook D, Meade M; et al. (2008). "Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin". Arch Intern Med 168 (16): 1805–1812. doi:10.1001/archinte.168.16.1805. PMID 18779469.
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