Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase

Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
Identifiers
EC number 1.1.1.333
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase (EC 1.1.1.333, decaprenylphospho-beta-D-ribofuranose 2'-epimerase, Rv3791, DprE2) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ \rightleftharpoons trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+

The reaction is catalysed in the reverse direction.

References

  1. Trefzer, C., Škovierová, H., Buroni, S., Bobovská, A., Nenci, S., Molteni, E., Pojer, F., Pasca, M.R., Makarov, V., Cole, S.T., Riccardi, G., Mikušová, K. and Johnsson, K. (2012). "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2-oxidase DprE1". J. Am. Chem. Soc. 134 (2): 912–915. doi:10.1021/ja211042r. PMID 22188377.

External links

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