Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase (EC 1.1.1.333, decaprenylphospho-beta-D-ribofuranose 2'-epimerase, Rv3791, DprE2) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+
The reaction is catalysed in the reverse direction.
References
- ↑ Trefzer, C., Škovierová, H., Buroni, S., Bobovská, A., Nenci, S., Molteni, E., Pojer, F., Pasca, M.R., Makarov, V., Cole, S.T., Riccardi, G., Mikušová, K. and Johnsson, K. (2012). "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1". J. Am. Chem. Soc. 134 (2): 912–915. doi:10.1021/ja211042r. PMID 22188377.
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