Delta11-fatty-acid desaturase

Delta11-fatty-acid desaturase (EC 1.14.19.5, Delta11 desaturase, fatty acid Delta11-desaturase, TpDESN, Cro-PG, Delta11 fatty acid desaturase, Z/E11-desaturase, Delta11-palmitoyl-CoA desaturase) is an enzyme with systematic name acyl-CoA,hydrogen donor:oxygen Delta11-oxidoreductase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

acyl-CoA + reduced acceptor + O₂

\rightleftharpoons

Delta11-acyl-CoA + acceptor + 2 H₂O

The enzyme from the marine microalga Thalassiosira pseudonana desaturates palmitic acid 16:0 to 16:1Delta11, whereas that from the leafroller moth Choristoneura rosaceana desaturates myristic acid 14:0 to 14:1Delta11.

References

↑ Tonon, T., Harvey, D., Qing, R., Li, Y., Larson, T.R. and Graham, I.A. (2004). "Identification of a fatty acid Δ¹¹-desaturase from the microalga Thalassiosira pseudonana". FEBS Lett. 563 (1-3): 28–34. doi:10.1016/S0014-5793(04)00241-8. PMID 15063718.
↑ Hao, G., O'Connor, M., Liu, W. and Roelofs, W.L. (2002). "Characterization of Z/E11- and Z9-desaturases from the obliquebanded leafroller moth, Choristoneura rosaceana". J. Insect Sci. 2:26: 1–7.
↑ Rodriguez, F., Hallahan, D.L., Pickett, J.A. and Camps, F. (1992). "Characterization of the Δ¹¹-palmitoyl-CoA-desaturase from Spodoptera littoralis (Lepidoptera:Noctuidae)". Insect Biochem. Mol. Biol. 22: 143–148.

External links

Delta11-fatty-acid desaturase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)

1.14.11: 2-oxoglutarate	Prolyl hydroxylase Lysyl hydroxylase

1.14.13: NADH or NADPH	Flavin-containing monooxygenase FMO1 FMO2 FMO3 FMO4 FMO5 Nitric oxide synthase NOS1 NOS2 NOS3 Cholesterol 7 alpha-hydroxylase Methane monooxygenase 3A4 Lanosterol 14 alpha-demethylase 24-hydroxycholesterol 7α-hydroxylase

1.14.14: reduced flavin or flavoprotein	19A1 2D6 2E1

1.14.15: reduced iron-sulfur protein	11B1 11B2 11A1

1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase Tyrosine hydroxylase Tryptophan hydroxylase

1.14.17: reduced ascorbate	Dopamine beta-hydroxylase

1.14.18-19: other	Tyrosinase Stearoyl-CoA desaturase-1

1.14.99 - miscellaneous	Cyclooxygenase Heme oxygenase (HMOX1) Squalene monooxygenase 17A1 21A2

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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