Delta12-fatty-acid desaturase

Delta12-fatty-acid desaturase
Identifiers
EC number	1.14.19.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Delta12-fatty-acid desaturase (EC 1.14.19.6, Delta12 fatty acid desaturase, Delta12(omega6)-desaturase, oleoyl-CoA Delta12 desaturase, Delta12 desaturase, Delta12-desaturase) is an enzyme with systematic name acyl-CoA,hydrogen donor:oxygen Delta12-oxidoreductase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

acyl-CoA + reduced acceptor + O₂ $\rightleftharpoons$ Delta12-acyl-CoA + acceptor + 2 H₂O

In the yeast Lipomyces starkeyi and in the American cockroach, this microsomal enzyme converts oleoyl-CoA into linoleoyl-CoA.

References

1. Borgeson, C.E., de Renobales, M. and Blomquist, G.J. (1990). "Characterization of the Δ¹² desaturase in the American cockroach, Periplaneta americana: the nature of the substrate". Biochim. Biophys. Acta 1047: 135–140. doi:10.1016/0005-2760(90)90039-z. PMID 2248971.
2. Jurenka, R.A. (1997). "Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a Δ¹² desaturase". Cell. Mol. Life Sci. 53: 501–505. doi:10.1007/s000180050062. PMID 9230926.
3. Lomascolo, A., Dubreucq, E. and Galzy, P. (1996). "Study of the Δ¹²-desaturase system of Lipomyces starkeyi". Lipids 31: 253–259. doi:10.1007/bf02529871. PMID 8900454.
4. Tocher, D.R., Leaver, M.J. and Hodgson, P.A. (1998). "Recent advances in the biochemistry and molecular biology of fatty acyl desaturases". Prog. Lipid Res. 37: 73–117. doi:10.1016/s0163-7827(98)00005-8. PMID 9829122.

External links

• Delta12-fatty-acid desaturase at the US National Library of Medicine Medical Subject Headings (MeSH)