Dermatan 4-sulfotransferase

Dermatan 4-sulfotransferase (EC 2.8.2.35, dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase, dermatan-4-sulfotransferase-1, dermatan-4-sulfotransferase 1, D4ST-1, dermatan N-acetylgalactosamine 4-O-sulfotransferase, CHST14 protein, CHST14) is an enzyme with systematic name 3'-phospho-5'-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine

\rightleftharpoons

adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine

The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan.

References

↑ Evers, M.R., Xia, G., Kang, H.G., Schachner, M. and Baenziger, J.U. (2001). "Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase". J. Biol. Chem. 276: 36344–36353. doi:10.1074/jbc.M105848200. PMID 11470797.
↑ Mikami, T., Mizumoto, S., Kago, N., Kitagawa, H. and Sugahara, K. (2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". J. Biol. Chem. 278: 36115–36127. doi:10.1074/jbc.M306044200. PMID 12847091.
↑ Pacheco, B., Maccarana, M. and Malmstrom, A. (2009). "Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate". Glycobiology 19 (11): 1197–1203. doi:10.1093/glycob/cwp110. PMID 19661164.
↑ Mitsunaga, C., Mikami, T., Mizumoto, S., Fukuda, J. and Sugahara, K. (2006). "Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases". J. Biol. Chem. 281 (28): 18942–18952. doi:10.1074/jbc.M510870200. PMID 16702220.

External links

Dermatan 4-sulfotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: sulfur-containing group (EC 2.8)

2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase

2.8.2: Sulfotransferases	Alcohol sulfotransferase Tyrosylprotein sulfotransferase Aryl sulfotransferase

2.8.3: CoA-transferases	Propionate CoA-transferase

2.8.4: Alkylthio	Coenzyme-B sulfoethylthiotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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