Dihydroorotate dehydrogenase (quinone)

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Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2, dihydroorotate:ubiquinone oxidoreductase, (S)-dihydroorotate:(acceptor) oxidoreductase, (S)-dihydroorotate:acceptor oxidoreductase, DHOdehase (ambiguous), DHOD (ambiguous), DHODase (ambiguous), DHODH) is an enzyme with systematic name (S)-dihydroorotate:quinone oxidoreductase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

(S)-dihydroorotate + a quinone

\rightleftharpoons

orotate + a quinol

This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.

References

↑ Forman, H.J. and Kennedy, J. (1978). "Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme". Arch. Biochem. Biophys. 191 (1): 23–31. doi:10.1016/0003-9861(78)90063-2. PMID 216313.
↑ Hines, V., Keys, L.D., III and Johnston, M. (1986). "Purification and properties of the bovine liver mitochondrial dihydroorotate dehydrogenase". J. Biol. Chem. 261 (24): 11386–11392. PMID 3733756.
↑ Bader, B., Knecht, W., Fries, M. and Löffler, M. (1998). "Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase". Protein Expr. Purif. 13 (3): 414–422. doi:10.1006/prep.1998.0925. PMID 9693067.
↑ Fagan, R.L., Nelson, M.N., Pagano, P.M. and Palfey, B.A. (2006). "Mechanism of flavin reduction in Class 2 dihydroorotate dehydrogenases". Biochemistry 45 (50): 14926–14932. doi:10.1021/bi060919g. PMID 17154530.
↑ Björnberg, O., Grüner, A.C., Roepstorff, P. and Jensen, K.F. (1999). "The activity of Escherichia coli dihydroorotate dehydrogenase is dependent on a conserved loop identified by sequence homology, mutagenesis, and limited proteolysis". Biochemistry 38: 2899–2908. doi:10.1021/bi982352c. PMID 10074342.

External links

Dihydroorotate dehydrogenase (quinone) at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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