Germacrene A hydroxylase
Germacrene A hydroxylase (EC 1.14.13.123) is an enzyme with systematic name (+)-germacrene-A,NADPH:oxygen oxidoreductase (12-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
- (+)-germacrene A + NADPH + H+ + O2
germacra-1(10),4,11(13)-trien-12-ol + NADP+ + H2O
Germacrene A hydroxylase is a heme-thiolate protein (P-450).
References
- ↑ de Kraker, J.W., Franssen, M.C., Dalm, M.C., de Groot, A. and Bouwmeester, H.J. (2001). "Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene A hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis". Plant Physiol. 125: 1930–1940. doi:10.1104/pp.125.4.1930. PMC 88848. PMID 11299372.
- ↑ Nguyen, D.T., Gopfert, J.C., Ikezawa, N., Macnevin, G., Kathiresan, M., Conrad, J., Spring, O. and Ro, D.K. (2010). "Biochemical conservation and evolution of germacrene A oxidase in asteraceae". J. Biol. Chem. 285: 16588–16598. doi:10.1074/jbc.M110.111757. PMC 2878029. PMID 20351109.
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