Cholate—CoA ligase

Cholate—CoA ligase
Identifiers
EC number 6.2.1.7
CAS number 9027-90-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Cholate—CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase, cholate thiokinase, cholic acid:CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase, THCA-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming), cholyl-CoA synthetase, trihydroxycoprostanoyl-CoA synthetase) is an enzyme with systematic name cholate:CoA ligase (AMP-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

(1) ATP + cholate + CoA \rightleftharpoons AMP + diphosphate + choloyl-CoA
(2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA \rightleftharpoons AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA

This enzyme requires Mg2+ for activity.

References

  1. Elliott, W.H. (1956). "The enzymic activation of cholic acid by guinea-pig-liver microsomes". Biochem. J. 62 (3): 427–433. PMID 13303991.
  2. Elliott, W.H. (1957). "The breakdown of adenosine triphosphate accompanying cholic acid activation by guinea-pig liver microsomes". Biochem. J. 65 (2): 315–321. PMID 13403911.
  3. Prydz, K., Kase, B.F., Björkhem, I. and Pedersen, J.I. (1988). "Subcellular localization of 3α,7α-dihydroxy- and 3α,7α,12α-trihydroxy-5β-cholestanoyl-coenzyme A ligase(s) in rat liver". J. Lipid Res. 29 (8): 997–1004. PMID 3183523.
  4. Schepers, L., Casteels, M., Verheyden, K., Parmentier, G., Asselberghs, S., Eyssen, H.J. and Mannaerts, G.P. (1989). "Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver". Biochem. J. 257 (1): 221–229. PMID 2521999.
  5. Mallonee, D.H., Adams, J.L. and Hylemon, P.B. (1992). "The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase". J. Bacteriol. 174 (7): 2065–2071. PMID 1551828.
  6. Wheeler, J.B., Shaw, D.R. and Barnes, S. (1997). "Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes". Arch. Biochem. Biophys. 348 (1): 15–24. doi:10.1006/abbi.1997.0391. PMID 9390170.
  7. Falany, C.N., Xie, X., Wheeler, J.B., Wang, J., Smith, M., He, D. and Barnes, S. (2002). "Molecular cloning and expression of rat liver bile acid CoA ligase". J. Lipid Res. 43: 2062–2071. doi:10.1194/jlr.M200260-JLR200. PMID 12454267.

External links

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