Cholate—CoA ligase
Cholate—CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase, cholate thiokinase, cholic acid:CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase, THCA-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming), cholyl-CoA synthetase, trihydroxycoprostanoyl-CoA synthetase) is an enzyme with systematic name cholate:CoA ligase (AMP-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) ATP + cholate + CoA
AMP + diphosphate + choloyl-CoA
- (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA
AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
This enzyme requires Mg2+ for activity.
References
- ↑ Elliott, W.H. (1956). "The enzymic activation of cholic acid by guinea-pig-liver microsomes". Biochem. J. 62 (3): 427–433. PMID 13303991.
- ↑ Elliott, W.H. (1957). "The breakdown of adenosine triphosphate accompanying cholic acid activation by guinea-pig liver microsomes". Biochem. J. 65 (2): 315–321. PMID 13403911.
- ↑ Prydz, K., Kase, B.F., Björkhem, I. and Pedersen, J.I. (1988). "Subcellular localization of 3α,7α-dihydroxy- and 3α,7α,12α-trihydroxy-5β-cholestanoyl-coenzyme A ligase(s) in rat liver". J. Lipid Res. 29 (8): 997–1004. PMID 3183523.
- ↑ Schepers, L., Casteels, M., Verheyden, K., Parmentier, G., Asselberghs, S., Eyssen, H.J. and Mannaerts, G.P. (1989). "Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver". Biochem. J. 257 (1): 221–229. PMID 2521999.
- ↑ Mallonee, D.H., Adams, J.L. and Hylemon, P.B. (1992). "The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase". J. Bacteriol. 174 (7): 2065–2071. PMID 1551828.
- ↑ Wheeler, J.B., Shaw, D.R. and Barnes, S. (1997). "Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes". Arch. Biochem. Biophys. 348 (1): 15–24. doi:10.1006/abbi.1997.0391. PMID 9390170.
- ↑ Falany, C.N., Xie, X., Wheeler, J.B., Wang, J., Smith, M., He, D. and Barnes, S. (2002). "Molecular cloning and expression of rat liver bile acid CoA ligase". J. Lipid Res. 43: 2062–2071. doi:10.1194/jlr.M200260-JLR200. PMID 12454267.
External links
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| 6.1: Carbon-Oxygen | |
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| 6.2: Carbon-Sulfur | |
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| 6.3: Carbon-Nitrogen | |
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