Esthesioneuroblastoma

Esthesioneuroblastoma

Esthesioneuroblastoma
Classification and external resources
Specialty oncology
ICD-10 C30.0
ICD-9-CM 160.0
ICD-O M9522/3
OMIM 133450
DiseasesDB 32047
eMedicine med/748
MeSH D018304

Esthesioneuroblastoma is a rare form of cancer involving the nasal cavity. It can cause loss of vision and taste.[1][2] It is often considered synonymous with "olfactory neuroblastoma"[3] and is believed to arise from the olfactory epithelium, but the exact tissue of origin is not yet well characterized. It is associated with trisomy 8.[4]

It was first characterized in 1924.[5][6]

Incidence/prevalence

According to the BBC, in 2008 only 201 cases of the disease had been recorded worldwide in the preceding two decades.[7]

A 1997 literature search identified 1,457 cases in the published literature since its discovery in 1924; however, 487 were cited in more than one paper, bringing the total of reported cases to 945.[8]

Treatment

Several surgical approaches have been described,[9][10][11][12] but post-excision recurrence rates have remained relatively high.

Notable cases

The disease was brought into prominence by the case of Chantal Sébire, who was suffering from the disease and ended her life after being denied euthanasia.[13]

See also

References

  1. ↑ Sharma S, Sharma MC, Johnson MH, Lou M, Thakar A, Sarkar C (2007). "Esthesioneuroblastoma - a clinicopathologic study and role of DNA topoisomerase alpha" (Template:Date=April 2009 – Scholar search). Pathol. Oncol. Res. 13 (2): 123–9. doi:10.1007/BF02893487. PMID 17607373.
  2. ↑ http://www.brisbanetimes.com.au/articles/2008/03/18/1205602424048.html
  3. ↑ "Medcyclopaedia - Esthesioneuroblastoma". Archived from the original on 2012-02-05. Retrieved 2008-03-22.
  4. ↑ VanDevanter, D. R.; George, D; McNutt, M. A.; Vogel, A.; Luthardt, F. (1991). "Trisomy 8 in primary esthesioneuroblastoma.". Cancer Genet Cytogenet 57 (1): 133–136. PMID 1756479.
  5. ↑ "Esthesioneuroblastoma". Archived from the original on April 9, 2007. Retrieved 2008-03-22.
  6. ↑ Berger L, Luc G, Richard D. L'esthésioneuroépithéliome olfactif. Bull Assoc Franç Étude Cancer 1924;13:410-421.
  7. ↑ "Tumour woman's death not natural". BBC News. 2008-03-21. Retrieved 2008-03-22.
  8. ↑ Broich G, Pagliari A, Ottaviani F (1997). "Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924". Anticancer Res. 17 (4A): 2683–706. PMID 9252701.
  9. ↑ Vergani F, Pirola E, Fiori L, Pagni F, Parmigiani F, Sganzerla EP (2007). "Combined transcranial and endoscopic nasal resection for esthesioneuroblastoma. Technical note". J Neurosurg Sci 51 (2): 99–102. PMID 17571044.
  10. ↑ Unger F, Walch C, Stammberger H, Papaefthymiou G, Haselsberger K, Pendl G (2001). "Olfactory neuroblastoma (esthesioneuroblastoma): report of six cases treated by a novel combination of endoscopic surgery and radiosurgery". Minim Invasive Neurosurg 44 (2): 79–84. doi:10.1055/s-2001-16000. PMID 11487789.
  11. ↑ Cakmak O, Ergin NT, Yilmazer C, Kayaselçuk F, Barutcu O (2002). "Endoscopic removal of esthesioneuroblastoma". Int. J. Pediatr. Otorhinolaryngol. 64 (3): 233–8. doi:10.1016/S0165-5876(02)00036-8. PMID 12090952.
  12. ↑ Prasad KC, Kumar A, Prasad SC, Jain D (2007). "Endoscopic-assisted excision of esthesioneuroblastoma". J Craniofac Surg 18 (5): 1034–8. doi:10.1097/scs.0b013e318157264c. PMID 17912077.
  13. ↑ Tumour woman's death not natural BBC 21 March 2008
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