Etofamide

Etofamide
Systematic (IUPAC) name

2,2-dichloro-N-(2-ethoxyethyl)-N- [4-(4-nitrophenoxy)benzyl]acetamide
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Legal status	℞ (Prescription only)
Identifiers
CAS Number	25287-60-9^Y
ATC code	P01AC03 (WHO)
PubChem	CID 65718
ChemSpider	59142
UNII	03F36JH21U^Y
KEGG	D07355^Y
ChEMBL	CHEMBL1788393
Chemical data
Formula	C₁₉H₂₀Cl₂N₂O₅
Molar mass	427.27 g/mol
SMILES CCOCCN(CC1=CC=C(C=C1)OC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(Cl)Cl
InChI InChI=1S/C19H20Cl2N2O5/c1-2-27-12-11-22(19(24)18(20)21)13-14-3-7-16(8-4-14)28-17-9-5-15(6-10-17)23(25)26/h3-10,18H,2,11-13H2,1H3 Key:QTRALMGDQMIVFF-UHFFFAOYSA-N
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Etofamide (INN, also known as eticlordifene) is an antiprotozoal drug used in the treatment of amoebiasis.

Its effect against Giardia lamblia has been described as modest.^[1]

References

↑ Cedillo-Rivera R, Muñoz O (September 1992). "In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents". J. Med. Microbiol. 37 (3): 221–4. doi:10.1099/00222615-37-3-221. PMID 1518040.

Antiparasitics – antiprotozoal agents – agents against amoebozoa/amebicide (P01)

Entamoeba

Tissue amebicides

Nitroimidazole derivatives	Metronidazole^# Tinidazole Ornidazole Nimorazole Secnidazole Azanidazole Propenidazole

Other	isoquinoline (Emetine/Dehydroemetine)

Luminal amebicides

Hydroxyquinoline derivatives	Cl (Chlorquinaldol) Br (Tilbroquinol Broxyquinoline) I (Diiodohydroxyquinoline) I, Cl (Clioquinol) related: Chiniofon

Dichloroacetamide derivatives	Diloxanide^# Clefamide Etofamide Teclozan

Aminoglycoside	Paromomycin

Other/ungrouped

Acanthamoeba

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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