Exosome component 4

Exosome component 4
PDB rendering based on 2nn6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2NN6​
Identifiers
Symbols	EXOSC4 ; RRP41; RRP41A; Rrp41p; SKI6; Ski6p; hRrp41p; p12A
External IDs	OMIM: 606491 MGI: 1923576 HomoloGene: 6017 GeneCards: EXOSC4 Gene
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • exoribonuclease activity • protein binding • AU-rich element binding Cellular component • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) • exosome (RNase complex) • nucleus • nucleolus • cytoplasm • cytosol • transcriptionally active chromatin Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • maturation of 5.8S rRNA • nuclear-transcribed mRNA catabolic process • rRNA processing • gene expression • rRNA catabolic process • positive regulation of cell growth • rRNA 3'-end processing • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • U4 snRNA 3'-end processing • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • DNA deamination • defense response to virus • nuclear mRNA surveillance • histone mRNA catabolic process • polyadenylation-dependent snoRNA 3'-end processing • RNA phosphodiester bond hydrolysis, exonucleolytic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54512	109075
Ensembl	ENSG00000178896	ENSMUSG00000034259
UniProt	Q9NPD3	Q921I9
RefSeq (mRNA)	NM_019037	NM_175399
RefSeq (protein)	NP_061910	NP_780608
Location (UCSC)	Chr 8: 144.08 – 144.08 Mb	Chr 15: 76.33 – 76.33 Mb
PubMed search

Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex.^[1]

Interactions

Exosome component 4 has been shown to interact with Exosome component 2.^[2]

References

1. "Entrez Gene: EXOSC4 exosome component 4".
2. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.

Further reading

• Allmang C, Petfalski E, Podtelejnikov A; et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
• Brouwer R, Allmang C, Raijmakers R; et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Chen CY, Gherzi R, Ong SE; et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Vree Egberts WT, Hengstman GJ; et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2003). "The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.". J. Biol. Chem. 278 (33): 30698–704. doi:10.1074/jbc.M302488200. PMID 12788944.
• Lejeune F, Li X, Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.". Mol. Cell 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• van Dijk EL, Schilders G, Pruijn GJ (2007). "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways.". RNA 13 (7): 1027–35. doi:10.1261/rna.575107. PMC 1894934. PMID 17545563.