Exosome component 7

Exosome component 7
PDB rendering based on 2nn6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2NN6​
Identifiers
Symbols	EXOSC7 ; EAP1; RRP42; Rrp42p; hRrp42p; p8
External IDs	OMIM: 606488 MGI: 1913696 HomoloGene: 8994 GeneCards: EXOSC7 Gene
EC number	3.1.13.-
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • RNA binding • exoribonuclease activity • protein binding Cellular component • exosome (RNase complex) • nucleus • nucleolus • cytosol Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • rRNA processing • RNA catabolic process • gene expression • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • RNA phosphodiester bond hydrolysis, exonucleolytic Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23016	66446
Ensembl	ENSG00000075914	ENSMUSG00000025785
UniProt	Q15024	Q9D0M0
RefSeq (mRNA)	NM_015004	NM_001081188
RefSeq (protein)	NP_055819	NP_001074657
Location (UCSC)	Chr 3: 44.98 – 45.04 Mb	Chr 9: 123.11 – 123.14 Mb
PubMed search

Exosome component 7, also known as EXOSC7, is a human gene, the protein product of which is part of the exosome complex.^[1]

Interactions

Exosome component 7 has been shown to interact with:

• Exosome component 1,^[2][3]
• Exosome component 2,^[2] and
• Exosome component 6.^[2]

References

1. "Entrez Gene: EXOSC7 exosome component 7".
2. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.
3. Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.

Further reading

• Butler JS (2002). "The yin and yang of the exosome.". Trends Cell Biol. 12 (2): 90–6. doi:10.1016/S0962-8924(01)02225-5. PMID 11849973.
• Nagase T, Miyajima N, Tanaka A; et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Brouwer R, Allmang C, Raijmakers R; et al. (2001). "Three novel components of the human exosome.". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Chen CY, Gherzi R, Ong SE; et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits.". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Vree Egberts WT, Hengstman GJ; et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.