Time release technology

Time release technology (also known as sustained-release [SR], extended-release [ER, XR, XL], controlled-release [CR], and other synonyms) is a mechanism used in pill tablets or capsules to dissolve a drug over time in order to be released slower and steadier into the bloodstream while having the advantage of being taken at less frequent intervals than immediate-release (IR) formulations of the same drug. For example, extended-release morphine allows for people with chronic pain to only need one or two tablets per day. The earliest SR drugs is associated with a patent in 1938 by Israel Lipowski, who coated pellets which led to coating particles.^[1]

List of abbreviations

There is no industry standard for these abbreviations, and confusion and misreading have sometimes caused prescribing errors.^[2] Clear handwriting is necessary. For some drugs with multiple formulations, putting the meaning in parentheses is advisable.

Abbreviation	Meaning	Notes
CD	controlled delivery
CR	controlled release
DR	delayed release
ER	extended release
IR	immediate release
LA	long-acting
MR	modified release
SA	sustained action	Ambiguous, can sometimes mean short-acting
SR	sustained release
TR	timed release
XL	extended release
XR	extended release
XT	extended release

A few other abbreviations are similar to these (in that they may serve as suffixes) but refer to dose rather than release rate. They include ES and XS (extra strength).

Methods

Today, most time-release drugs are formulated so that the active ingredient is embedded in a matrix of insoluble substance(s) (various: some acrylics, even chitin; these substances are often patented) such that the dissolving drug must find its way out through the holes in the matrix.

In some SR formulations, the drug dissolves into the matrix, and the matrix physically swells to form a gel, allowing the drug to exit through the gel's outer surface.

Micro-encapsulation is also regarded as a more complete technology to produce complex dissolution profiles. Through coating an active pharmaceutical ingredient around an inert core, and layering it with insoluble substances to form a microsphere one can obtain more consistent and replicable dissolution rates in a convenient format that can be mixed and matched with other instant release pharmaceutical ingredients in to any two piece gelatin capsule.

There are certain considerations for the formation of sustained-release formulation:

• If the pharmacological activity of the active compound is not related to its blood levels, time releasing has no purpose except in some cases, such as bupropion, to reduce possible side effects.
• If the absorption of the active compound involves an active transport, the development of a time-release product may be problematic.

The half-life of the drug refers to the drug's elimination from the bloodstream which can be caused by metabolism, urine, and other forms of excretion. If the active compound has a long half-life (over 6 hours), it is sustained on its own.If the active compound has a short half-life, it would require a large amount to maintain a prolonged effective dose. In this case, a broad therapeutic window is necessary to avoid toxicity; otherwise, the risk is unwarranted and another mode of administration would be recommended. ^[3] Appropriate half-lifes used to apply sustained methods are typically 3-4 hours and a drug greater than 0.5 grams is too big.^[4][5]

The therapeutic index also factors whether a drug can be used as a time release drug. A drug with a thin therapeutic range, or small therapeutic index, will be determined unfit for a sustained release mechanism in partial fear of dose dumping which can prove fatal at the conditions mentioned.^[6] For a drug that is made to be released over time, the general goals is to stay within the therapeutic range as long as needed.^[3]

There are many different methods used to obtain a sustained release.

Diffusion Systems

Diffusion systems rate release is dependent on the rate at which the drug dissolves through a barrier which is usually a type of polymer. Diffusion systems can be broken into two subcategories, reservoir devices and matrix devices.^[3]

• Reservoir devices coat the drug with polymers and in order for the reservoir devices to have sustained release effects, the polymer must not dissolve and let the drug be released through diffusion.^[3] The rate of reservoir devices can be altered by changing the polymer and is possible be made to have zero-order release; however, drugs with higher molecular weight have difficulty diffusing through the membrane.^[1][7]
• Matrix devices forms a matrix (drug(s) mixed with a gelling agent)^[8] where the drug is dissolved/dispersed.^[7] The drug is usually dispersed within a polymer and then released by undergoing diffusion. However, to make the drug SR in this device, the rate of dissolution of the drug within the matrix needs to be higher than the rate at which it is released.3 The matrix device cannot achieve a zero-order release but higher molecular weight molecules can be used.^[1] The diffusion matrix device also tends to be easier to produce and protect from changing in the gastrointestinal tract but factors such as food can affect the release rate.^[6]

Dissolution Systems

Dissolution systems must have the system dissolved slowly in order for the drug to have sustained release properties which can be achieved by using appropriate salts and/or derivatives as well as coating the drug with a dissolving material.^[3] It is used for drug compounds with high solubility in water.^[6] When the drug is covered with some slow dissolving coat, it will eventually release the drug. Instead of diffusion, the drug release depends on the solubility and thickness of the coating. Because of this mechanism, the dissolution will be the rate limiting factor here for drug release.^[3] Dissolution systems can be broken down to subcategories called reservoir devices and matrix devices.^[6]

• The reservoir device coats the drug with an appropriate material which will dissolve slowly. It can also be used to administer beads as a group with varying thickness, making the drug release in multiple times creating a SR.^[6]
• The matrix device has the drug in a matrix and the matrix is dissolved instead of a coating. It can come either as drug impregnated spheres or drug impregnated tablets.^[6]

Osmotic Systems

A system where the membrane does not allow the drug diffuse outside the membrane but the body fluid on the exterior of the membrane can diffuse into the membrane, allowing the drug to release through channels within the membrane.^[3] Some drugs are enclosed in polymer-based tablets with a laser-drilled hole on one side and a porous membrane on the other side. Stomach acids push through the porous membrane, thereby pushing the drug out through the laser-drilled hole. In time, the entire drug dose releases into the system while the polymer container remains intact, to be excreted later.^[9] This method is used for hydrophilic drug and allows zero-order release.^[6] This method can be in two forms: the core of the membrane contains the drug as a solid or in a solution. The osmotic system (solid drug core) will have electrolytes which provide high osmotic pressure and is dissolved by incoming fluids.^[3]

Ion-exchange Resin

In the ion-exchange method, the resins are cross-linked water-insoluble polymers that contain ionisable functional groups that form a repeating pattern of polymers, creating a polymer chain.^[3][6] The drug is attached to the resin and is released when an appropriate interaction of ions and ion exchange groups occur. The area and length of the drug release and number of cross-link polymers dictate the rate at which the drug is released, determining the SR effect.^[6]

Floating Systems

A floating system is a system where it floats on gastric fluids due to low-density. The density of the gastric fluids is about 1 mg/mL; thus, the drug/tablet administered must have a smaller density. The buoyancy will allow the system to float to the top of the stomach and release at a slower rate without worry of excreting it. This system requires there are enough gastric fluids present as well as food.^[3] Many types of forms of drugs use this method such as powders, capsules, and tablets.^[9]

Bio-Adhesive Systems

Bio-adhesive systems generally are meant to stick to mucus and can be favorable for mouth based interactions due to high mucus in the general area but not as simple for other areas. Magnetic materials can be added to the drug so another magnet can hold it from outside the body to assist in holding the system in place. However, there low patient compliance with this system.^[3]

Matrix Systems

The matrix system is the mixture of materials with the drug, which will cause the drug to slow down. However, this system has several subcategories: hydrophobic matrices, lipid matrices, hydrophilic matrices, biodegradable matrices, and mineral matrices.^[3]

• A hydrophobic matrix is a drug mixed with a hydrophobic polymer. This causes SR because the drug, after being dissolved, will have to be released by going through channels made by the hydrophilic polymer.^[3]
• A hydrophilic matrix will go back to the matrix as discussed before where a matrix is a mixture of a drug or drugs with a gelling agent.^[3] This system is well liked because of its cost and broad regulatory acceptance. The polymers used can be broken down into categories: cellulose derivatives, non-cellulose natural, and polymers of acrylic acid.^[10]
• A lipid matrix uses wax or similar materials. Drug release happens through diffusion through, and erosion of, the wax and tends to be sensitive to digestive fluids.^[3]
• Biodegradable matrices are made with unstable, linked monomers that will erode by biological compounds such as enzymes and proteins.^[3]
• A mineral matrix which generally means the polymers used are obtained in seaweed.^[3]

Pill splitting

Empty half-shell of a split bupropion XL 150mg manufactured by Anchen Pharmaceuticals that was soaked in water overnight and then shaken.

Some time release formulations do not work properly if split, such as controlled-release tablet coatings, while other formulations such as micro-encapsulation still work if the microcapsules inside are swallowed whole.^[11][12]

Among the health information technology (HIT) that pharmacists use are medication safety tools to help manage this problem. For example, the ISMP "do not crush" list^[13] can be entered into the system so that warning stickers can be printed at the point of dispensing, to be stuck on the pill bottle.

Pharmaceutical companies that do not supply a range of half-dose and quarter-dose versions of time-release tablets can make it difficult for patients to be slowly tapered off their drugs.

See also

• Tablet (pharmacy)
• Depot injection

References

1. Navin Dixit, Sheo Dutt Maurya, and Bhanu Sagar. Sustained Release Drug Delivery System. Indian Journal of Research in Pharmacy and Biotechnology. 2013. Accessed: May 30, 2016.
2. Pennsylvania Patient Safety Authority (December 2004), "Drug name suffix confusion is a common source of errors", PA PSRS Patient Saf Advis 1 (4): 17–18.
3. Lilesh Khalane, Atulal Kunte, and Arunadevi Blrajdar. Sustained Release Drug Delivery System: A Concise Review. Pharmatutor: pharmacy infopedia. 2016. Accessed: May 30, 2016.
4. Sampath kumar, Debjit Bhowmik, Shweta Srivastava, Shravan Paswan, and A. Dutta. Sustained. Release Drug Delivery System Potential. The Pharma Innovation. 2012. Accessed: May 30, 2016.
5. Kapil Patil, Prashant Patil , Javesh Patil , and Sunil Pawar. A Basic Approach on Sustained Release Drug Delivery System. American Journal of PharmTech Research. 2011. Accessed: May 30, 2016.
6. Ratnaparkhi P. and Gupta P.. Sustained Release Oral Drug Delivery System – An Overveiw. International Journal of Pharma Research & Review. 2013. Accessed: May 30, 2016.
7. Perrie, Y., & Rades, T. Pharmaceutics: Drug delivery and targeting. London: Pharmaceutical Press. Accessed: May 30, 2016.
8. Tarun Parashar, Soniya, Vishal Singh, Gaurav Singh, Satyanand Tyagi, Chirag Patel, and Anil Gupta. International Journal of Research and Development in Pharmacy and Life Sciences. Novel Oral Sustained Release Technology: A Concise Review. 2013. Accessed: May 30, 2016.
9. Dusane Ratilal, Gaikwad D., Banker H., and Pawar P. A Review On: Sustained Release Technology. International Journal of Research in Ayurveda and Pharmacy. 2011. Accessed: May 30, 2016.
10. Jaimini Manish and Kothari Abhay. Sustained Release Matrix Type Drug Delivery System: A Review. Journal of Drug Delivery & Therapeutics. 2012. Accessed: May 30, 2016.
11. http://www.netdoctor.co.uk/medicines/100004842.html
12. Vranić, E; Uzunović, A (August 2009). "Influence of splitting on dissolution properties of metoprolol tablets.". Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences 9 (3): 245–9. PMID 19754482.
13. Institute for Safe Medication Practices (ISMP), ISMP "do not crush" list: Oral dosage forms that should not be crushed (PDF)