FABP1

Fatty acid binding protein 1, liver

PDB rendering based on 2f73.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2F73, 2L67, 2L68, 2LKK, 2PY1, 3B2H, 3B2I, 3B2J, 3B2K, 3B2L, 3STK, 3STM, 3STN, 3VG2, 3VG3, 3VG4, 3VG5, 3VG6, 3VG7

Identifiers

Symbols

FABP1 ; FABPL; L-FABP

External IDs

OMIM: 134650 MGI: 95479 HomoloGene: 1106 ChEMBL: 5421 GeneCards: FABP1 Gene

Gene ontology
Molecular function	• chromatin binding • long-chain fatty acid transporter activity • fatty acid binding • protein binding • phospholipid binding • drug binding • antioxidant activity • bile acid binding
Cellular component	• nucleoplasm • peroxisomal matrix • cytosol • apical cortex • extracellular exosome
Biological process	• positive regulation of defense response to virus by host • positive regulation of cell proliferation • long-chain fatty acid transport • triglyceride catabolic process • positive regulation of fatty acid beta-oxidation • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular lipid metabolic process • small molecule metabolic process • intestinal absorption • positive regulation of hydrolase activity • cellular response to hydrogen peroxide • cellular response to hypoxia • activation of mitophagy in response to mitochondrial depolarization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
88.12 – 88.13 Mb

Chr 6:
71.2 – 71.21 Mb

PubMed search

Fatty acid-binding protein 1 (FABP1) also known as liver-type fatty acid-binding protein (L-FABP) is a protein that in humans is encoded by the FABP1 gene.^[1]^[2]^[3]

Function

FABP1 encodes the fatty acid-binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.^[3]

References

↑ Chen SH, Van Tuinen P, Ledbetter DH, Smith LC, Chan L (Jul 1986). "Human liver fatty acid binding protein gene is located on chromosome 2". Somat Cell Mol Genet 12 (3): 303–6. doi:10.1007/BF01570790. PMID 3012800.
↑ Weickert MO, Loeffelholz CV, Roden M, Chandramouli V, Brehm A, Nowotny P, Osterhoff MA, Isken F, Spranger J, Landau BR, Pfeiffer AF, Mohlig M (Oct 2007). "A Thr94Ala mutation in human liver fatty acid-binding protein contributes to reduced hepatic glycogenolysis and blunted elevation of plasma glucose levels in lipid-exposed subjects". Am J Physiol Endocrinol Metab 293 (4): E1078–84. doi:10.1152/ajpendo.00337.2007. PMID 17698986.
1 2 "Entrez Gene: FABP1 fatty acid binding protein 1, liver".

Glatz JF, Börchers T, Spener F, van der Vusse GJ (1995). "Fatty acids in cell signalling: modulation by lipid binding proteins.". Prostaglandins Leukot. Essent. Fatty Acids 52 (2–3): 121–7. doi:10.1016/0952-3278(95)90010-1. PMID 7784447.
Kaikaus RM, Chan WK, Ortiz de Montellano PR, Bass NM (1993). "Mechanisms of regulation of liver fatty acid-binding protein". Mol. Cell. Biochem. 123 (1–2): 93–100. doi:10.1007/BF01076479. PMID 8232272.
Londraville RL (1997). "Intracellular fatty acid-binding proteins: putting lower vertebrates in perspective". Braz. J. Med. Biol. Res. 29 (6): 707–20. PMID 9070383.
Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids 57 (1): 77–84. doi:10.1016/S0952-3278(97)90496-8. PMID 9250612.
Carroll SL, Roth KA, Gordon JI (1990). "Liver fatty acid-binding protein: a marker for studying cellular differentiation in gut epithelial neoplasms". Gastroenterology 99 (6): 1727–35. PMID 1699834.
Sweetser DA, Birkenmeier EH, Klisak IJ; et al. (1987). "The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships". J. Biol. Chem. 262 (33): 16060–71. PMID 2824476.
Chan L, Wei CF, Li WH; et al. (1985). "Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications". J. Biol. Chem. 260 (5): 2629–32. PMID 3838309.
Lowe JB, Boguski MS, Sweetser DA; et al. (1985). "Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins". J. Biol. Chem. 260 (6): 3413–7. PMID 3838313.
Murphy EJ (1998). "L-FABP and I-FABP expression increase NBD-stearate uptake and cytoplasmic diffusion in L cells". Am. J. Physiol. 275 (2 Pt 1): G244–9. PMID 9688651.
Wolfrum C, Börchers T, Sacchettini JC, Spener F (2000). "Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver". Biochemistry 39 (6): 1469–74. doi:10.1021/bi991638u. PMID 10684629.
Wolfrum C, Borrmann CM, Borchers T, Spener F (2001). "Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2323–8. doi:10.1073/pnas.051619898. PMC 30137. PMID 11226238.
Schroeder F, Atshaves BP, Starodub O; et al. (2001). "Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells". Mol. Cell. Biochem. 219 (1–2): 127–38. doi:10.1023/A:1010851130136. PMID 11354243.
Zimmerman AW, van Moerkerk HT, Veerkamp JH (2001). "Ligand specificity and conformational stability of human fatty acid-binding proteins". Int. J. Biochem. Cell Biol. 33 (9): 865–76. doi:10.1016/S1357-2725(01)00070-X. PMID 11461829.
Mésange F, Sebbar M, Capdevielle J; et al. (2003). "Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone". Bioconjug. Chem. 13 (4): 766–72. doi:10.1021/bc015588t. PMID 12121132.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

PDB gallery

2f73: Crystal structure of human fatty acid binding protein 1 (FABP1)

Proteins: carrier proteins

Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7

Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin

Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor

Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin

Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin

Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

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FABP1

Function

References

Further reading