IGFBP5

Insulin-like growth factor binding protein 5

PDB rendering based on 1boe.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1BOE, 1H59

Identifiers

Symbols

IGFBP5 ; IBP5

External IDs

OMIM: 146734 MGI: 96440 HomoloGene: 56489 ChEMBL: 2665 GeneCards: IGFBP5 Gene

Gene ontology
Molecular function	• fibronectin binding • protein binding • insulin-like growth factor I binding • insulin-like growth factor II binding
Cellular component	• extracellular region • extracellular space • intracellular • insulin-like growth factor binding protein complex • insulin-like growth factor ternary complex
Biological process	• regulation of cell growth • osteoblast differentiation • glucose metabolic process • signal transduction • regulation of glucose metabolic process • negative regulation of smooth muscle cell migration • negative regulation of translation • negative regulation of cell migration • hair follicle morphogenesis • intracellular signal transduction • glucose homeostasis • positive regulation of insulin-like growth factor receptor signaling pathway • negative regulation of insulin-like growth factor receptor signaling pathway • cellular protein metabolic process • type B pancreatic cell proliferation • negative regulation of osteoblast differentiation • skeletal muscle tissue growth • negative regulation of smooth muscle cell proliferation • striated muscle cell differentiation • positive regulation of protein kinase B signaling • mammary gland involution • response to growth hormone • cellular response to cAMP • cellular response to organic cyclic compound
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
216.67 – 216.7 Mb

Chr 1:
72.86 – 72.87 Mb

PubMed search

Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene.^[1]

References

↑ Allander SV, Larsson C, Ehrenborg E, Suwanichkul A, Weber G, Morris SL, Bajalica S, Kiefer MC, Luthman H, Powell DR (May 1994). "Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5". J Biol Chem 269 (14): 10891–8. PMID 7511611.

Mohan S, Farley JR, Baylink DJ (1996). "Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging.". Prog. Growth Factor Res. 6 (2–4): 465–73. doi:10.1016/0955-2235(95)00027-5. PMID 8817691.
Schneider MR, Wolf E, Hoeflich A, Lahm H (2002). "IGF-binding protein-5: flexible player in the IGF system and effector on its own". J. Endocrinol. 172 (3): 423–40. doi:10.1677/joe.0.1720423. PMID 11874691.
Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
Shimasaki S, Shimonaka M, Zhang HP, Ling N (1991). "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human". J. Biol. Chem. 266 (16): 10646–53. PMID 1709938.
Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112.
Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. 176 (1): 213–8. doi:10.1016/0006-291X(91)90911-P. PMID 1850257.
Kiefer MC, Ioh RS, Bauer DM, Zapf J (1991). "Molecular cloning of a new human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 176 (1): 219–25. doi:10.1016/0006-291X(91)90912-Q. PMID 1850258.
Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544.
Kou K, James PL, Clemmons DR, et al. (1994). "Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11". Genomics 21 (3): 653–5. doi:10.1006/geno.1994.1329. PMID 7525452.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nam TJ, Busby W, Clemmons DR (1997). "Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I". Endocrinology 138 (7): 2972–8. doi:10.1210/en.138.7.2972. PMID 9202242.
Twigg SM, Baxter RC (1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074–9. doi:10.1074/jbc.273.11.6074. PMID 9497324.
Zheng B, Clarke JB, Busby WH, et al. (1998). "Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin". Endocrinology 139 (4): 1708–14. doi:10.1210/en.139.4.1708. PMID 9528953.
Twigg SM, Kiefer MC, Zapf J, Baxter RC (1998). "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain". J. Biol. Chem. 273 (44): 28791–8. doi:10.1074/jbc.273.44.28791. PMID 9786878.
Kalus W, Zweckstetter M, Renner C, et al. (1999). "Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions". EMBO J. 17 (22): 6558–72. doi:10.1093/emboj/17.22.6558. PMC 1171003. PMID 9822601.
Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.
Kecha O, Martens H, Franchimont N, et al. (1999). "Characterization of the insulin-like growth factor axis in the human thymus". J. Neuroendocrinol. 11 (6): 435–40. doi:10.1046/j.1365-2826.1999.00343.x. PMID 10336724.

PDB gallery

1boe: STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS

1h59: COMPLEX OF IGFBP-5 WITH IGF-I

Proteins: carrier proteins

Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7

Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin

Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor

Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin

Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin

Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

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IGFBP5

References

Further reading