FMNL2
| Formin-like 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FMNL2 ; FHOD2 | ||||||||||||
| External IDs | OMIM: 616285 MGI: 1918659 HomoloGene: 70871 GeneCards: FMNL2 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 114793 | 71409 | |||||||||||
| Ensembl | ENSG00000157827 | ENSMUSG00000036053 | |||||||||||
| UniProt | Q96PY5 | A2APV2 | |||||||||||
| RefSeq (mRNA) | NM_001004417 | NM_172409 | |||||||||||
| RefSeq (protein) | NP_443137 | NP_765997 | |||||||||||
| Location (UCSC) |
Chr 2: 152.34 – 152.65 Mb |
Chr 2: 52.86 – 53.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[1][2]
Expression
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[1] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[3]) is regulated through autoinhibition, and may become activated through Rho proteins.[4] The FMNL2 gene is expressed in multiple human tissues.[5]
Function
Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[1]
Clinical significance
FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[6]
See also
References
- 1 2 3 "Entrez Gene: FMNL2 formin-like 2".
- ↑ Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
- ↑ "formin-like protein 2 [Homo sapiens]" (NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R (April 2010). "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC". Oncogene 29 (16): 2441–8. doi:10.1038/onc.2009.515. PMID 20101212.
- ↑ Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O (2010). "Characterization of Diaphanous-related formin FMNL2 in human tissues". BMC Cell Biol. 11: 55. doi:10.1186/1471-2121-11-55. PMC 2912821. PMID 20633255.
- ↑ Zhu XL, Liang L, Ding YQ (November 2008). "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer". Int J Colorectal Dis 23 (11): 1041–7. doi:10.1007/s00384-008-0520-2. PMID 18665374.
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