FMNL3

Formin-like 3
Identifiers
Symbols	FMNL3 ; FHOD3; FRL2; WBP-3; WBP3
External IDs	OMIM: 616288 MGI: 109569 HomoloGene: 69101 GeneCards: FMNL3 Gene
Gene ontology Molecular function • actin binding • Rho GTPase binding • GTPase activating protein binding Cellular component • cytoplasm • cytosol • plasma membrane Biological process • angiogenesis • cytoskeleton organization • small GTPase mediated signal transduction • regulation of cell shape • cell migration • actin cytoskeleton organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	91010	22379
Ensembl	ENSG00000161791	ENSMUSG00000023008
UniProt	Q8IVF7	Q6ZPF4
RefSeq (mRNA)	NM_175736	NM_011711
RefSeq (protein)	NP_783863	NP_035841
Location (UCSC)	Chr 12: 49.64 – 49.71 Mb	Chr 15: 99.32 – 99.37 Mb
PubMed search

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.^[1][2]

Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.^[1] The C-terminus has been shown to accelerate actin polymerization activity of this protein through it's WH2-like motif.^[3] FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.^[4]

See also

• FMNL1
• FMNL2

References

1. "Entrez Gene: formin-like 3".
2. Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
3. Heimsath EG, Higgs HN (Jan 2012). "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends". The Journal of Biological Chemistry 287 (5): 3087–98. doi:10.1074/jbc.M111.312207. PMC 3270965. PMID 22094460.
4. Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation". Nature Structural & Molecular Biology 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC 3876896. PMID 23222643.

Further reading

• Bedford MT, Chan DC, Leder P (May 1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". The EMBO Journal 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC 1169838. PMID 9171351.