Ferredoxin hydrogenase

ferredoxin hydrogenase
Identifiers
EC number	1.12.7.2
CAS number	9080-02-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a ferredoxin hydrogenase (EC 1.12.7.2) is an enzyme that catalyzes the chemical reaction

H₂ + 2 oxidized ferredoxin $\rightleftharpoons$ 2 reduced ferredoxin + 2 H⁺

Thus, the two substrates of this enzyme are H₂ and oxidized ferredoxin, whereas its two products are reduced ferredoxin and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is hydrogen:ferredoxin oxidoreductase. Other names in common use include H2 oxidizing hydrogenase, H2 producing hydrogenase [ambiguous], bidirectional hydrogenase, hydrogen-lyase [ambiguous], hydrogenase (ferredoxin), hydrogenase I, hydrogenase II, hydrogenlyase [ambiguous], and uptake hydrogenase [ambiguous]. This enzyme participates in glyoxylate and dicarboxylate metabolism and methane metabolism. It has 3 cofactors: iron, Sulfur, and Nickel.

References

• Shug AL, Wilson PW, Green DE and Mahler HR (1954). "The role of molybdenum and flavin in hydrogenase". J. Am. Chem. Soc. 76 (12): 3355–3356. doi:10.1021/ja01641a090.
• Tagawa K and Arnon DI. "Ferredoxin as electron carriers in photosynthesis and in the bioogical production and consumption of hydrogen gas". N (Lond.). Nature: 537–543.
• Valentine RC, Mortenson LE and Carnahan JE (1963). "The hydrogenase system of Clostridium pasteurianum". J. Biol. Chem. 238: 1141–1144.
• Zumft WG, Mortenson LE (1975). "The nitrogen-fixing complex of bacteria". Biochim. Biophys. Acta 416 (1): 1–52. doi:10.1016/0304-4173(75)90012-9. PMID 164247.
• Adams MW (1990). "The structure and mechanism of iron-hydrogenases". Biochim. Biophys. Acta 1020 (2): 115–45. doi:10.1016/0005-2728(90)90044-5. PMID 2173950.
• Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC (1998). "X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution". Science. 282 (5395): 1853–8. doi:10.1126/science.282.5395.1853. PMID 9836629.