Hydrogen dehydrogenase (NADP+)

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AUV.

References

de Luca G, de Philip P, Rousset M, Belaich JP, Dermoun Z (1998). "The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity". Biochem. Biophys. Res. Commun. 248 (3): 591–6. doi:10.1006/bbrc.1998.9022. PMID 9703971.

Oxidoreductases: Acting on hydrogen as donor (EC 1.12)

1.12.1	Hydrogen dehydrogenase Hydrogen dehydrogenase (NADP+) Hydrogenase (NAD+, ferredoxin)

1.12.2	Cytochrome-c3 hydrogenase

1.12.5	Hydrogen:quinone oxidoreductase

1.12.7	Ferredoxin hydrogenase

1.10.98	Coenzyme F420 hydrogenase 5,10-Methenyltetrahydromethanopterin hydrogenase Methanosarcina-phenazine hydrogenase Sulfhydrogenase

1.10.99	Hydrogenase (acceptor)

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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