Flavanone 3-dioxygenase

naringenin 3-dioxygenase
Identifiers
EC number	1.14.11.9
CAS number	75991-43-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a flavanone 3-dioxygenase (EC 1.14.11.9) is an enzyme that catalyzes the chemical reaction

a flavanone + 2-oxoglutarate + O₂ $\rightleftharpoons$ a dihydroflavonol + succinate + CO₂

The 3 substrates of this enzyme are flavanone, 2-oxoglutarate, and O₂, whereas its 3 products are dihydroflavonol, succinate, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). Other names in common use include naringenin 3-hydroxylase, flavanone 3-hydroxylase, flavanone 3beta-hydroxylase, flavanone synthase I, (2S)-flavanone 3-hydroxylase, and naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). This enzyme participates in flavonoid biosynthesis. It has 2 cofactors: iron, and Ascorbate.

References

• Forkmann G, Heller W and Grisebach H (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3- and flavonoid 3'-hydroxylases". Z. Naturforsch. C: Biosci. 35: 691–695.
• Wellmann F, Matern U, Lukacin R (2004). "Significance of C-terminal sequence elements for Petunia flavanone 3beta-hydroxylase activity". FEBS Lett. 561 (1-3): 149–54. doi:10.1016/S0014-5793(04)00159-0. PMID 15013767.