Flavin containing monooxygenase 3

Flavin containing monooxygenase 3
Identifiers
Symbols	FMO3 ; FMOII; TMAU; dJ127D3.1
External IDs	OMIM: 136132 MGI: 1100496 HomoloGene: 128199 GeneCards: FMO3 Gene
EC number	1.14.13.148, 1.14.13.8
Gene ontology Molecular function • N,N-dimethylaniline monooxygenase activity • trimethylamine monooxygenase activity • flavin adenine dinucleotide binding • NADP binding Cellular component • endoplasmic reticulum membrane • integral component of membrane • intracellular membrane-bounded organelle Biological process • xenobiotic metabolic process • drug metabolic process • small molecule metabolic process • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2328	14262
Ensembl	ENSG00000007933	ENSMUSG00000026691
UniProt	P31513	P97501
RefSeq (mRNA)	NM_001002294	NM_008030
RefSeq (protein)	NP_001002294	NP_032056
Location (UCSC)	Chr 1: 171.09 – 171.12 Mb	Chr 1: 162.95 – 162.98 Mb
PubMed search

Dimethylaniline monooxygenase [N-oxide-forming] 3 is an enzyme that in humans is encoded by the FMO3 gene.^[1][2][3]

See also

• Flavin-containing monooxygenase
• Trimethylaminuria

References

1. Shephard EA, Dolphin CT, Fox MF, Povey S, Smith R, Phillips IR (Jun 1993). "Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q". Genomics 16 (1): 85–9. doi:10.1006/geno.1993.1144. PMID 8486388.
2. Dolphin CT, Riley JH, Smith RL, Shephard EA, Phillips IR (Feb 1998). "Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA". Genomics 46 (2): 260–7. doi:10.1006/geno.1997.5031. PMID 9417913.
3. "Entrez Gene: FMO3 flavin containing monooxygenase 3".

External links

• GeneReviews/NCBI/NIH/UW entry on Trimethylaminuria or Fish Odor Syndrome

Further reading

• Cashman JR, Park SB, Berkman CE, Cashman LE (1995). "Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans.". Chem. Biol. Interact. 96 (1): 33–46. doi:10.1016/0009-2797(94)03581-R. PMID 7720103.
• Cashman JR (2004). "The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development.". Drug Discov. Today 9 (13): 574–81. doi:10.1016/S1359-6446(04)03136-8. PMID 15203093.
• Zhou J, Shephard EA (2006). "Mutation, polymorphism and perspectives for the future of human flavin-containing monooxygenase 3.". Mutat. Res. 612 (3): 165–71. doi:10.1016/j.mrrev.2005.09.001. PMID 16481213.
• Lomri N, Gu Q, Cashman JR (1992). "Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1685–9. doi:10.1073/pnas.89.5.1685. PMC 48517. PMID 1542660.
• Humbert JA, Hammond KB, Hathaway WE (1970). "Trimethylaminuria: the fish-odour syndrome.". Lancet 2 (7676): 770–1. doi:10.1016/S0140-6736(70)90241-2. PMID 4195988.
• Higgins T, Chaykin S, Hammond KB, Humbert JR (1972). "Trimethylamine N-oxide synthesis: a human variant.". Biochemical medicine 6 (4): 392–6. doi:10.1016/0006-2944(72)90025-7. PMID 5048998.
• Lomri N, Gu Q, Cashman JR (1995). "Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9910. doi:10.1073/pnas.92.21.9910. PMC 40912. PMID 7568243.
• Bhamre S, Bhagwat SV, Shankar SK; et al. (1995). "Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomes.". Brain Res. 672 (1–2): 276–80. doi:10.1016/0006-8993(94)01135-5. PMID 7749747.
• Cashman JR, Park SB, Yang ZC; et al. (1993). "Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine". Drug Metab. Dispos. 21 (4): 587–97. PMID 8104117.
• Park SB, Jacob P, Benowitz NL, Cashman JR (1994). "Stereoselective metabolism of (S)-(−)-nicotine in humans: formation of trans-(S)-(−)-nicotine N-1'-oxide". Chem. Res. Toxicol. 6 (6): 880–8. doi:10.1021/tx00036a019. PMID 8117928.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Dolphin CT, Cullingford TE, Shephard EA; et al. (1996). "Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04". Eur. J. Biochem. 235 (3): 683–9. doi:10.1111/j.1432-1033.1996.00683.x. PMID 8654418.
• Chung WG, Cha YN (1997). "Oxidation of caffeine to theobromine and theophylline is catalyzed primarily by flavin-containing monooxygenase in liver microsomes". Biochem. Biophys. Res. Commun. 235 (3): 685–8. doi:10.1006/bbrc.1997.6866. PMID 9207220.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dolphin CT, Janmohamed A, Smith RL; et al. (1997). "Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome". Nat. Genet. 17 (4): 491–4. doi:10.1038/ng1297-491. PMID 9398858.
• Treacy EP, Akerman BR, Chow LM; et al. (1998). "Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication". Hum. Mol. Genet. 7 (5): 839–45. doi:10.1093/hmg/7.5.839. PMID 9536088.
• Akerman BR, Forrest S, Chow L; et al. (1999). "Two novel mutations of the FMO3 gene in a proband with trimethylaminuria". Hum. Mutat. 13 (5): 376–9. doi:10.1002/(SICI)1098-1004(1999)13:5<376::AID-HUMU5>3.0.CO;2-A. PMID 10338091.