Flavonoid 3'-monooxygenase

flavonoid 3'-monooxygenase
Identifiers
EC number	1.14.13.21
CAS number	85340-98-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a flavonoid 3'-monooxygenase (EC 1.14.13.21) is an enzyme that catalyzes the chemical reaction^[1]

a flavonoid + NADPH + H⁺ + O₂ $\rightleftharpoons$ a 3'-hydroxyflavonoid + NADP⁺ + H₂O

The 4 substrates of this enzyme are flavonoid, NADPH, H⁺, and O₂, whereas its 3 products are 3'-hydroxyflavonoid, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating). Other names in common use include flavonoid 3'-hydroxylase, flavonoid 3-hydroxylase (erroneous), NADPH:flavonoid-3'-hydroxylase, and flavonoid 3-monooxygenase (erroneous). This enzyme participates in flavonoid biosynthesis.

References

1. Forkmann, G., Heller, W. and Grisebach, H. (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3- and flavonoid 3'-hydroxylases". Z. Naturforsch. C: Biosci. 35: 691–695.