Foreign body granuloma

Foreign body granuloma
Transvaginal ultrasonography showing a foreign body granuloma at right as a hypoechoic (dark) area around a perforated intrauterine device. The uterus is at left.
Classification and external resources
Specialty	dermatology
ICD-10	L92.3 (ILDS L92.300)

A foreign-body response to talc (talcosis) due to intravenous drug use. H&E stain.

The foreign body granuloma is a response of biological tissue to any foreign material in the tissue.^[1] Tissue-encapsulation of an implant is part of this. An infection around a splinter is part of this, too.^[2]

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR). FBR consists of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis.

It can be caused by beryllium.^[3]

References

↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1443. ISBN 1-4160-2999-0.
↑ Biomaterials Science Second edition, Ratner et al. Pp. 296-304
↑ Haley PJ (1991). "Mechanisms of granulomatous lung disease from inhaled beryllium: the role of antigenicity in granuloma formation". Toxicologic pathology 19 (4 Pt 1): 514–25. doi:10.1177/019262339101900417. PMID 1813991.

Cutaneous keratosis, ulcer, atrophy, and necrobiosis (L82–L94, 700–701.5)

Epidermal thickening

Necrobiosis/granuloma

Necrobiotic/palisading	Granuloma annulare Perforating Generalized Subcutaneous Granuloma annulare in HIV disease Localized granuloma annulare Patch-type granuloma annulare Necrobiosis lipoidica Annular elastolytic giant cell granuloma Granuloma multiforme Necrobiotic xanthogranuloma Palisaded neutrophilic and granulomatous dermatitis Rheumatoid nodulosis Interstitial granulomatous dermatitis/Interstitial granulomatous drug reaction

Foreign body granuloma	Beryllium granuloma Mercury granuloma Silica granuloma Silicone granuloma Zirconium granuloma Soot tattoo Tattoo Carbon stain

Other/ungrouped	eosinophilic dermatosis Granuloma faciale

Dermis/
localized CTD

Cutaneous lupus erythematosus	chronic: Discoid Panniculitis subacute: Neonatal ungrouped: Chilblain Lupus erythematosus–lichen planus overlap syndrome Tumid Verrucous Rowell's syndrome

Scleroderma/ Morphea	Localized scleroderma Localized morphea Morphea–lichen sclerosus et atrophicus overlap Generalized morphea Atrophoderma of Pasini and Pierini Pansclerotic morphea Morphea profunda Linear scleroderma

Atrophic/ atrophoderma	Lichen sclerosus Anetoderma Schweninger–Buzzi anetoderma Jadassohn–Pellizzari anetoderma Atrophoderma of Pasini and Pierini Acrodermatitis chronica atrophicans Semicircular lipoatrophy Follicular atrophoderma Linear atrophoderma of Moulin

Perforating	Kyrle disease Reactive perforating collagenosis Elastosis perforans serpiginosa Perforating folliculitis Acquired perforating dermatosis

Skin ulcer	Pyoderma gangrenosum

Other	Calcinosis cutis Sclerodactyly Poikiloderma vasculare atrophicans Ainhum/Pseudo-ainhum

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Foreign body granuloma

See also

References