Formate dehydrogenase-N

Formate dehydrogenase-N (EC 1.1.5.6, Fdh-N, FdnGHI, nitrate-inducible formate dehydrogenase, formate dehydrogenase N, FDH-N, nitrate inducible Fdn, nitrate inducible formate dehydrogenase) is an enzyme with systematic name formate:quinone oxidoreductase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

formate + quinone

\rightleftharpoons

CO₂ + quinol

This enzyme contains molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters and two heme b groups.

References

↑ Enoch, H.G. and Lester, R.L. (1975). "The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli". J. Biol. Chem. 250 (17): 6693–6705. PMID 1099093.
↑ Jormakka, M., Tornroth, S., Byrne, B. and Iwata, S. (2002). "Molecular basis of proton motive force generation: structure of formate dehydrogenase-N". Science 295: 1863–1868. doi:10.1126/science.1068186. PMID 11884747.
↑ Jormakka, M., Tornroth, S., Abramson, J., Byrne, B. and Iwata, S. (2002). "Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 1): 160–162. doi:10.1107/s0907444901017723. PMID 11752799.

External links

Formate dehydrogenase-N at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: alcohol oxidoreductases (EC 1.1)

1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Phosphogluconate dehydrogenase Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3 Beta 3-beta-HSD NSDHL 11 Beta HSD11B1 HSD11B2 17 Beta

1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)

1.1.3: oxygen acceptor	Glucose oxidase L-gulonolactone oxidase Xanthine oxidase

1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)

1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase

1.1.99: other acceptors	Choline dehydrogenase L2HGDH

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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