Furylfuramide isomerase

furylfuramide isomerase
Identifiers
EC number	5.2.1.6
CAS number	72561-07-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a furylfuramide isomerase (EC 5.2.1.6) is an enzyme that catalyzes the chemical reaction

(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide $\rightleftharpoons$ (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide

Hence, this enzyme has one substrate, (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, and one product, (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase. It has 2 cofactors: NAD+, and NADH.

References

• Tomoeda M, Kitamura R (1977). "A cis-trans isomerising activity of Escherichia coli. Isomerization from 2-(2-furyl)-3-cis-(5-nitro-2-furyl) acrylamide (furylfuramide) to its trans isomer". Biochim. Biophys. Acta 480 (1): 315–25. doi:10.1016/0005-2744(77)90344-8. PMID 12827.