GORASP1

Golgi reassembly stacking protein 1, 65kDa
Identifiers
Symbols GORASP1 ; GOLPH5; GRASP65; P65
External IDs OMIM: 606867 MGI: 1921748 HomoloGene: 49916 GeneCards: GORASP1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 64689 74498
Ensembl ENSG00000114745 ENSMUSG00000032513
UniProt Q9BQQ3 Q91X51
RefSeq (mRNA) NM_001278789 NM_028976
RefSeq (protein) NP_001265718 NP_083252
Location (UCSC) Chr 3:
39.1 – 39.11 Mb
Chr 9:
119.93 – 119.94 Mb
PubMed search

Golgi reassembly-stacking protein 1 is a protein that in humans is encoded by the GORASP1 gene.[1]

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined.[1]

Interactions

GORASP1 has been shown to interact with TGF alpha,[2] TMED2[2] and GOLGA2.[2][3][4][5]

References

  1. 1 2 "Entrez Gene: GORASP1 golgi reassembly stacking protein 1, 65kDa".
  2. 1 2 3 Barr, F A; Preisinger C; Kopajtich R; Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. (United States) 155 (6): 885–91. doi:10.1083/jcb.200108102. ISSN 0021-9525. PMC 2150891. PMID 11739402.
  3. Marra, P; Maffucci T; Daniele T; Tullio G D; Ikehara Y; Chan E K; Luini A; Beznoussenko G; Mironov A; De Matteis M A (Dec 2001). "The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment". Nat. Cell Biol. (England) 3 (12): 1101–13. doi:10.1038/ncb1201-1101. ISSN 1465-7392. PMID 11781572.
  4. Short, B; Preisinger C; Körner R; Kopajtich R; Byron O; Barr F A (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. (United States) 155 (6): 877–83. doi:10.1083/jcb.200108079. ISSN 0021-9525. PMC 2150909. PMID 11739401.
  5. Shorter, J; Watson R; Giannakou M E; Clarke M; Warren G; Barr F A (Sep 1999). "GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system". EMBO J. (ENGLAND) 18 (18): 4949–60. doi:10.1093/emboj/18.18.4949. ISSN 0261-4189. PMC 1171566. PMID 10487747.

Further reading


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