TMED2

Transmembrane p24 trafficking protein 2
Identifiers
Symbols	TMED2 ; P24A; RNP24; p24
External IDs	MGI: 1929269 HomoloGene: 55991 GeneCards: TMED2 Gene
Gene ontology Molecular function • protein binding Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • endoplasmic reticulum-Golgi intermediate compartment • Golgi apparatus • integral component of membrane • COPI-coated vesicle • COPI-coated vesicle membrane • Golgi cisterna membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • zymogen granule membrane • intracellular membrane-bounded organelle Biological process • maternal placenta development • intracellular protein transport • ER to Golgi vesicle-mediated transport • Golgi organization • negative regulation of GTPase activity • cargo loading into vesicle • COPI coating of Golgi vesicle • COPII vesicle coating • embryonic morphogenesis • labyrinthine layer blood vessel development • protein targeting to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10959	56334
Ensembl	ENSG00000086598	ENSMUSG00000029390
UniProt	Q15363	Q9R0Q3
RefSeq (mRNA)	NM_006815	NM_019770
RefSeq (protein)	NP_006806	NP_062744
Location (UCSC)	Chr 12: 123.58 – 123.6 Mb	Chr 5: 124.54 – 124.55 Mb
PubMed search

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.^[1][2]

Interactions

TMED2 has been shown to interact with GORASP1^[3] and GORASP2.^[3]

References

1. Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (September 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". J Biol Chem 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
2. "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".
3. Barr, F A; Preisinger C; Kopajtich R; Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. (United States) 155 (6): 885–91. doi:10.1083/jcb.200108102. ISSN 0021-9525. PMC 2150891. PMID 11739402.

Further reading

• Fiedler K, Veit M, Stamnes MA, Rothman JE (1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors.". Science 273 (5280): 1396–9. doi:10.1126/science.273.5280.1396. PMID 8703076.
• Gommel D, Orci L, Emig EM, et al. (1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway.". FEBS Lett. 447 (2–3): 179–85. doi:10.1016/S0014-5793(99)00246-X. PMID 10214941.
• Majoul I, Straub M, Hell SW, et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Dev. Cell 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
• Barr FA, Preisinger C, Kopajtich R, Körner R (2002). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chen F, Hasegawa H, Schmitt-Ulms G, et al. (2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature 440 (7088): 1208–12. doi:10.1038/nature04667. PMID 16641999.
• Luo W, Wang Y, Reiser G (2007). "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking". J. Biol. Chem. 282 (41): 30246–55. doi:10.1074/jbc.M703205200. PMID 17693410.