GOSR2

Golgi SNAP receptor complex member 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3EG9​
Identifiers
Symbols	GOSR2 ; Bos1; EPM6; GS27
External IDs	OMIM: 604027 MGI: 1927204 HomoloGene: 37907 GeneCards: GOSR2 Gene
Gene ontology Molecular function • SNARE binding • transporter activity • SNAP receptor activity • protein binding Cellular component • Golgi membrane • endoplasmic reticulum membrane • Golgi apparatus • ER to Golgi transport vesicle membrane • membrane • integral component of membrane • SNARE complex • late endosome membrane Biological process • protein targeting to vacuole • ER to Golgi vesicle-mediated transport • intra-Golgi vesicle-mediated transport • Golgi to vacuole transport • endoplasmic reticulum unfolded protein response • IRE1-mediated unfolded protein response • retrograde transport, endosome to Golgi • cellular protein metabolic process • vesicle fusion with Golgi apparatus • membrane fusion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9570	56494
Ensembl	ENSG00000108433	ENSMUSG00000020946
UniProt	O14653	O35166
RefSeq (mRNA)	NM_001012511	NM_019650
RefSeq (protein)	NP_001012529	NP_062624
Location (UCSC)	Chr 17: 46.92 – 46.97 Mb	Chr 11: 103.68 – 103.7 Mb
PubMed search

Golgi SNAP receptor complex member 2 is a protein that in humans is encoded by the GOSR2 gene.^[1][2][3]

Function

This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Three transcript variants encoding three different isoforms have been found for this gene.^[3]

Interactions

GOSR2 has been shown to interact with USO1^[4][5] and STX5.^[4][6][7]

References

1. Lowe SL, Peter F, Subramaniam VN, Wong SH, Hong W (Oct 1997). "A SNARE involved in protein transport through the Golgi apparatus". Nature 389 (6653): 881–4. doi:10.1038/39923. PMID 9349823.
2. Bui TD, Levy ER, Subramaniam VN, Lowe SL, Hong W (Apr 1999). "cDNA characterization and chromosomal mapping of human golgi SNARE GS27 and GS28 to chromosome 17". Genomics 57 (2): 285–8. doi:10.1006/geno.1998.5649. PMID 10198168.
3. "Entrez Gene: GOSR2 golgi SNAP receptor complex member 2".
4. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
5. Allan BB, Moyer BD, Balch WE (Jul 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.
6. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
7. Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.

Further reading

• Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
• Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
• Xu D, Joglekar AP, Williams AL, Hay JC (Dec 2000). "Subunit structure of a mammalian ER/Golgi SNARE complex". The Journal of Biological Chemistry 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026. Check date values in: |year= / |date= mismatch (help)
• Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
• Honda A, Al-Awar OS, Hay JC, Donaldson JG (Mar 2005). "Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE". The Journal of Cell Biology 168 (7): 1039–51. doi:10.1083/jcb.200409138. PMC 2171843. PMID 15781476.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome : Official Journal of the International Mammalian Genome Society 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. Check date values in: |year= / |date= mismatch (help)