STX5

Syntaxin 5
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3EFO​
Identifiers
Symbols	STX5 ; SED5; STX5A
External IDs	OMIM: 603189 MGI: 1928483 HomoloGene: 2381 GeneCards: STX5 Gene
Gene ontology Molecular function • SNARE binding • SNAP receptor activity • protein binding • protein N-terminus binding Cellular component • Golgi membrane • nucleoplasm • endoplasmic reticulum • Golgi apparatus • endomembrane system • integral component of membrane • SNARE complex • vesicle • endoplasmic reticulum-Golgi intermediate compartment membrane Biological process • intracellular protein transport • ER to Golgi vesicle-mediated transport • vesicle fusion • early endosome to Golgi transport • retrograde transport, endosome to Golgi • positive regulation of protein catabolic process • vesicle docking • vesicle fusion with Golgi apparatus • Golgi disassembly • regulation of Golgi organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6811	56389
Ensembl	ENSG00000162236	ENSMUSG00000010110
UniProt	Q13190	Q8K1E0
RefSeq (mRNA)	NM_001244666	NM_001167799
RefSeq (protein)	NP_001231595	NP_001161271
Location (UCSC)	Chr 11: 62.81 – 62.83 Mb	Chr 19: 8.74 – 8.76 Mb
PubMed search

Syntaxin-5 is a protein that in humans is encoded by the STX5 gene.^[1][2][3]

Interactions

STX5 has been shown to interact with:

• BET1L,^[4][5]
• GOSR1,^[6][7][4][8]
• GOSR2,^[6][7][4]
• NAPA,^[9][10] and
• USO1.^[4][11]

References

1. Ravichandran V, Roche PA (Apr 1997). "Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein". Journal of Molecular Neuroscience 8 (2): 159–61. doi:10.1007/BF02736780. PMID 9188044.
2. Parlati F, Varlamov O, Paz K, McNew JA, Hurtado D, Söllner TH, Rothman JE (Apr 2002). "Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity". Proceedings of the National Academy of Sciences of the United States of America 99 (8): 5424–9. doi:10.1073/pnas.082100899. PMC 122785. PMID 11959998.
3. "Entrez Gene: STX5 syntaxin 5".
4. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
5. Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
6. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/s0092-8674(00)80191-9. PMID 9094723.
7. Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
8. Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex". The Journal of Biological Chemistry 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. PMID 9325254.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
10. Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G (Mar 1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell 92 (5): 603–10. doi:10.1016/s0092-8674(00)81128-9. PMID 9506515.
11. Allan BB, Moyer BD, Balch WE (Jul 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.

Further reading

• Nichols BJ, Pelham HR (Aug 1998). "SNAREs and membrane fusion in the Golgi apparatus". Biochimica Et Biophysica Acta 1404 (1-2): 9–31. doi:10.1016/S0167-4889(98)00044-5. PMID 9714710.
• Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
• Paek I, Orci L, Ravazzola M, Erdjument-Bromage H, Amherdt M, Tempst P, Söllner TH, Rothman JE (Jun 1997). "ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi". The Journal of Cell Biology 137 (5): 1017–28. doi:10.1083/jcb.137.5.1017. PMC 2136225. PMID 9166403.
• Rabouille C, Kondo H, Newman R, Hui N, Freemont P, Warren G (Mar 1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell 92 (5): 603–10. doi:10.1016/S0092-8674(00)81128-9. PMID 9506515.
• Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002. PMID 9647643.
• Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (Mar 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". Journal of Leukocyte Biology 65 (3): 397–406. PMID 10080545.
• Xu D, Joglekar AP, Williams AL, Hay JC (Dec 2000). "Subunit structure of a mammalian ER/Golgi SNARE complex". The Journal of Biological Chemistry 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026.
• Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
• Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
• Uchiyama K, Jokitalo E, Kano F, Murata M, Zhang X, Canas B, Newman R, Rabouille C, Pappin D, Freemont P, Kondo H (Dec 2002). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". The Journal of Cell Biology 159 (5): 855–66. doi:10.1083/jcb.200208112. PMC 2173386. PMID 12473691.
• Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC (Jan 2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins". Proceedings of the National Academy of Sciences of the United States of America 100 (1): 32–7. doi:10.1073/pnas.232701299. PMC 140874. PMID 12506202.
• Williams AL, Ehm S, Jacobson NC, Xu D, Hay JC (Jan 2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility". Molecular Biology of the Cell 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMC 307537. PMID 14565970.
• Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
• Suga K, Tomiyama T, Mori H, Akagawa K (Aug 2004). "Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production". The Biochemical Journal 381 (Pt 3): 619–28. doi:10.1042/BJ20040618. PMC 1133870. PMID 15109302.
• Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.