SYT6

Synaptotagmin VI
Identifiers
Symbols	SYT6 ; sytVI
External IDs	OMIM: 607718 MGI: 1859544 HomoloGene: 10301 GeneCards: SYT6 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • calcium-dependent phospholipid binding • syntaxin binding • clathrin binding • protein homodimerization activity • protein heterodimerization activity • calcium-dependent protein binding Cellular component • cytosol • plasma membrane • integral component of membrane • extrinsic component of membrane • cell junction • synaptic vesicle membrane • perinuclear endoplasmic reticulum Biological process • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis • calcium ion-dependent exocytosis of neurotransmitter • acrosomal vesicle exocytosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	148281	54524
Ensembl	ENSG00000134207	ENSMUSG00000027849
UniProt	Q5T7P8	Q9R0N8
RefSeq (mRNA)	NM_001253772	NM_001276676
RefSeq (protein)	NP_001257734	NP_001263605
Location (UCSC)	Chr 1: 114.09 – 114.15 Mb	Chr 3: 103.58 – 103.65 Mb
PubMed search

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.^[1][2]

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM]^[2]

References

1. Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
2. "Entrez Gene: SYT6 synaptotagmin VI".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Roggero CM, Tomes CN, De Blas GA, et al. (2006). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Dev. Biol. 285 (2): 422–35. doi:10.1016/j.ydbio.2005.07.007. PMID 16111671.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Michaut M, De Blas G, Tomes CN, et al. (2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Dev. Biol. 235 (2): 521–9. doi:10.1006/dbio.2001.0316. PMID 11437455.
• Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.