VAMP1

Vesicle-associated membrane protein 1 (synaptobrevin 1)
PDB rendering based on 1kil.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1kil​, 1n7s​
Identifiers
Symbols	VAMP1 ; SPAX1; SYB1; VAMP-1
External IDs	OMIM: 185880 MGI: 1313276 HomoloGene: 40678 ChEMBL: 2038 GeneCards: VAMP1 Gene
Gene ontology Molecular function • SNARE binding • SNAP receptor activity • protein binding Cellular component • mitochondrial outer membrane • cytosol • integral component of plasma membrane • synaptic vesicle • cell surface • cell junction • synaptic vesicle membrane • SNARE complex • azurophil granule membrane • specific granule membrane • terminal bouton • tertiary granule membrane Biological process • exocytosis • vesicle fusion • synaptic transmission • SNARE complex assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6843	22317
Ensembl	ENSG00000139190	ENSMUSG00000030337
UniProt	P23763	Q62442
RefSeq (mRNA)	NM_001297438	NM_001080557
RefSeq (protein)	NP_001284367	NP_001074026
Location (UCSC)	Chr 12: 6.46 – 6.47 Mb	Chr 6: 125.22 – 125.24 Mb
PubMed search

Vesicle-associated membrane protein 1 is a protein that in humans is encoded by the VAMP1 gene.^[1][2]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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Nicotine Activity on Dopaminergic Neurons edit

1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

1. Archer BT 3rd, Ozcelik T, Jahn R, Francke U, Sudhof TC (Nov 1990). "Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2". J Biol Chem 265 (28): 17267–73. PMID 1976629.
2. "Entrez Gene: VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)".

Further reading

• Ravichandran V, Chawla A, Roche PA (1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues.". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
• Jagadish MN, Fernandez CS, Hewish DR, et al. (1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2.". Biochem. J. 317. ( Pt 3): 945–54. doi:10.1042/bj3170945. PMC 1217577. PMID 8760387.
• Annaert WG, Becker B, Kistner U, et al. (1998). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.". J. Cell Biol. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
• Weir ML, Klip A, Trimble WS (1998). "Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.". Biochem. J. 333. ( Pt 2): 247–51. doi:10.1042/bj3330247. PMC 1219579. PMID 9657962.
• Isenmann S, Khew-Goodall Y, Gamble J, et al. (1999). "A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal.". Mol. Biol. Cell 9 (7): 1649–60. doi:10.1091/mbc.9.7.1649. PMC 25402. PMID 9658161.
• Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.
• Berglund L, Hoffmann HJ, Dahl R, Petersen TE (1999). "VAMP-1 has a highly variable C-terminus generated by alternative splicing.". Biochem. Biophys. Res. Commun. 264 (3): 777–80. doi:10.1006/bbrc.1999.1588. PMID 10544008.
• Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.