SYT3

Synaptotagmin III
PDB rendering based on 1dqv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1dqv​
Identifiers
Symbols	SYT3 ; SytIII
External IDs	OMIM: 600327 MGI: 99665 HomoloGene: 9617 GeneCards: SYT3 Gene
Gene ontology Molecular function • calcium ion binding • calcium-dependent phospholipid binding • syntaxin binding • clathrin binding Cellular component • endosome • plasma membrane • integral component of membrane • cell junction • synaptic vesicle membrane Biological process • synaptic vesicle exocytosis • calcium ion-dependent exocytosis • regulation of calcium ion-dependent exocytosis • calcium ion-dependent exocytosis of neurotransmitter • positive regulation of dendrite extension Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84258	20981
Ensembl	ENSG00000213023	ENSMUSG00000030731
UniProt	Q9BQG1	O35681
RefSeq (mRNA)	NM_001160328	NM_001114116
RefSeq (protein)	NP_001153800	NP_001107588
Location (UCSC)	Chr 19: 50.62 – 50.67 Mb	Chr 7: 44.38 – 44.4 Mb
PubMed search

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.^[1][2]

References

1. Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (Jun 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mamm Genome 6 (3): 212–213. doi:10.1007/BF00293017. PMID 7749232.
2. "Entrez Gene: SYT3 synaptotagmin III".

Further reading

• Li C, Ullrich B, Zhang JZ, et al. (1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–599. doi:10.1038/375594a0. PMID 7791877.
• Fukuda M, Kanno E, Mikoshiba K (1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X". J. Biol. Chem. 274 (44): 31421–31427. doi:10.1074/jbc.274.44.31421. PMID 10531343.
• Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes". J. Biol. Chem. 275 (9): 6328–6336. doi:10.1074/jbc.275.9.6328. PMID 10692432.
• Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–9831. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics 77 (1–2): 43–49. doi:10.1006/geno.2001.6619. PMID 11543631.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.