SYT9

Synaptotagmin IX
Identifiers
Symbols	SYT9 ; FLJ45896
External IDs	OMIM: 613528 MGI: 1926373 HomoloGene: 11062 GeneCards: SYT9 Gene
Gene ontology Molecular function • calcium ion binding • calcium-dependent phospholipid binding • syntaxin binding • clathrin binding • identical protein binding Cellular component • plasma membrane • integral component of membrane • cell junction • secretory granule membrane • synaptic vesicle membrane • dense core granule Biological process • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis • positive regulation of calcium ion-dependent exocytosis • calcium ion-dependent exocytosis of neurotransmitter • regulation of insulin secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	143425	60510
Ensembl	ENSG00000170743	ENSMUSG00000062542
UniProt	Q86SS6	Q9R0N9
RefSeq (mRNA)	NM_175733	NM_021889
RefSeq (protein)	NP_783860	NP_068689
Location (UCSC)	Chr 11: 7.24 – 7.47 Mb	Chr 7: 107.37 – 107.55 Mb
PubMed search

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.^[1][2]

Interactions

SYT9 has been shown to interact with SYNCRIP,^[3] TUBB^[4] and TRPV1.^[5]

References

1. Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics 77 (1-2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
2. "Entrez Gene: SYT9 synaptotagmin IX".
3. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
4. Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.
5. Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.
• Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

\* Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters 517 (1-3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.

• Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron 34 (4): 599–611. doi:10.1016/S0896-6273(02)00671-2. PMID 12062043.
• Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K (Feb 2002). "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells". The Journal of Biological Chemistry 277 (7): 4601–4. doi:10.1074/jbc.C100588200. PMID 11751925.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Perin MS (Oct 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.