TUBB

Tubulin, beta class I
PDB rendering based on 1ffx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3QNZ​, 3QO0​
Identifiers
Symbols	TUBB ; CDCBM6; M40; OK/SW-cl.56; TUBB1; TUBB5
External IDs	OMIM: 191130 MGI: 107812 HomoloGene: 69099 ChEMBL: 5444 GeneCards: TUBB Gene
Gene ontology Molecular function • GTPase activity • structural molecule activity • structural constituent of cytoskeleton • protein binding • GTP binding • protein domain specific binding • ubiquitin protein ligase binding • protein complex binding • GTPase activating protein binding • MHC class I protein binding Cellular component • nucleus • nuclear envelope lumen • cytosol • cytoskeleton • microtubule • cytoplasmic ribonucleoprotein granule • cell body • extracellular exosome Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • movement of cell or subcellular component • organelle organization • microtubule-based process • metabolic process • cellular process • cytoskeleton-dependent intracellular transport • natural killer cell mediated cytotoxicity • spindle assembly • protein polymerization • cell division Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	203068	22154
Ensembl	ENSG00000183311	ENSMUSG00000001525
UniProt	P07437	P99024
RefSeq (mRNA)	NM_001293212	NM_011655
RefSeq (protein)	NP_001280141	NP_035785
Location (UCSC)	Chr 6: 30.72 – 30.73 Mb	Chr 17: 35.83 – 35.84 Mb
PubMed search

Tubulin beta chain is a protein that in humans is encoded by the TUBB gene.^[1][2][3]

Interactions

TUBB has been shown to interact with NCOA6^[4] and SYT9.^[5]

See also

• Tubulin

References

1. Crabtree DV, Ojima I, Geng X, Adler AJ (Aug 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorganic & Medicinal Chemistry 9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID 11504633.
2. Volz A, Weiss E, Trowsdale J, Ziegler A (Jan 1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction". Human Genetics 93 (1): 42–6. doi:10.1007/BF00218911. PMID 8270253.
3. "Entrez Gene: TUBB tubulin, beta".
4. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968.
5. Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

Further reading

• Berrieman HK, Lind MJ, Cawkwell L (Mar 2004). "Do beta-tubulin mutations have a role in resistance to chemotherapy?". The Lancet. Oncology 5 (3): 158–64. doi:10.1016/S1470-2045(04)01411-1. PMID 15003198.
• Horisberger MA (Aug 1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". Journal of Virology 66 (8): 4705–9. PMC 241296. PMID 1629950.
• Wang D, Villasante A, Lewis SA, Cowan NJ (Nov 1986). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype". The Journal of Cell Biology 103 (5): 1903–10. doi:10.1083/jcb.103.5.1903. PMC 2114403. PMID 3782288.
• Lee MG, Lewis SA, Wilde CD, Cowan NJ (Jun 1983). "Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes". Cell 33 (2): 477–87. doi:10.1016/0092-8674(83)90429-4. PMID 6688039.
• Hall JL, Dudley L, Dobner PR, Lewis SA, Cowan NJ (May 1983). "Identification of two human beta-tubulin isotypes". Molecular and Cellular Biology 3 (5): 854–62. doi:10.1128/mcb.3.5.854. PMC 368608. PMID 6865944.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Kinnunen T, Kaksonen M, Saarinen J, Kalkkinen N, Peng HB, Rauvala H (Apr 1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". The Journal of Biological Chemistry 273 (17): 10702–8. doi:10.1074/jbc.273.17.10702. PMID 9553134.
• Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Apr 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762.
• Rasmussen RK, Ji H, Eddes JS, Moritz RL, Reid GE, Simpson RJ, Dorow DS (May 1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins". Electrophoresis 19 (5): 809–17. doi:10.1002/elps.1150190535. PMID 9629920.
• Ciruela F, Robbins MJ, Willis AC, McIlhinney RA (Jan 1999). "Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin". Journal of Neurochemistry 72 (1): 346–54. doi:10.1046/j.1471-4159.1999.0720346.x. PMID 9886087.
• Chau MF, Radeke MJ, de Inés C, Barasoain I, Kohlstaedt LA, Feinstein SC (Dec 1998). "The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains". Biochemistry 37 (51): 17692–703. doi:10.1021/bi9812118. PMID 9922135.
• Piredda L, Farrace MG, Lo Bello M, Malorni W, Melino G, Petruzzelli R, Piacentini M (Feb 1999). "Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis". FASEB Journal 13 (2): 355–64. PMID 9973324.
• Feng Y, Hodge DR, Palmieri G, Chase DL, Longo DL, Ferris DK (Apr 1999). "Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex". The Biochemical Journal 339 (2): 435–42. doi:10.1042/0264-6021:3390435. PMC 1220175. PMID 10191277.
• Martín L, Fanarraga ML, Aloria K, Zabala JC (Mar 2000). "Tubulin folding cofactor D is a microtubule destabilizing protein". FEBS Letters 470 (1): 93–5. doi:10.1016/S0014-5793(00)01293-X. PMID 10722852.
• Tarazona R, López-Lluch G, Galiani MD, Aguado E, Barahona F, Solana R, Peña J (Dec 2000). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity". Journal of Immunology 165 (12): 6776–82. doi:10.4049/jimmunol.165.12.6776. PMID 11120798.
• Bonnet C, Boucher D, Lazereg S, Pedrotti B, Islam K, Denoulet P, Larcher JC (Apr 2001). "Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation". The Journal of Biological Chemistry 276 (16): 12839–48. doi:10.1074/jbc.M011380200. PMID 11278895.
• Ivings L, Pennington SR, Jenkins R, Weiss JL, Burgoyne RD (May 2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". The Biochemical Journal 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513. PMID 11964161.