STX12

Syntaxin 12
PDB rendering based on 2dnx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DNX​
Identifiers
Symbols	STX12 ; STX13; STX14
External IDs	OMIM: 606892 MGI: 1931027 HomoloGene: 128192 GeneCards: STX12 Gene
Gene ontology Molecular function • SNARE binding • SNAP receptor activity • protein binding Cellular component • Golgi membrane • endosome membrane • endomembrane system • integral component of membrane • BLOC-1 complex • SNARE complex • membrane raft • phagocytic vesicle • extracellular exosome Biological process • intracellular protein transport • vesicle fusion • cholesterol efflux • vesicle docking • protein stabilization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23673	100226
Ensembl	ENSG00000117758	ENSMUSG00000028879
UniProt	Q86Y82	Q9ER00
RefSeq (mRNA)	NM_177424	NM_133887
RefSeq (protein)	NP_803173	NP_598648
Location (UCSC)	Chr 1: 27.77 – 27.82 Mb	Chr 4: 132.85 – 132.88 Mb
PubMed search

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.^[1][2]

Interactions

STX12 has been shown to interact with PLDN.^[3]

References

1. Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W (Apr 1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome". J Biol Chem 273 (12): 6944–50. doi:10.1074/jbc.273.12.6944. PMID 9507000.
2. "Entrez Gene: STX12 syntaxin 12".
3. Huang, L; Kuo Y M; Gitschier J (Nov 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nat. Genet. (UNITED STATES) 23 (3): 329–32. doi:10.1038/15507. ISSN 1061-4036. PMID 10610180.

Further reading

• Falcón-Pérez JM, Dell'Angelica EC (2002). "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis.". Pigment Cell Res. 15 (2): 82–6. doi:10.1034/j.1600-0749.2002.1r082.x. PMID 11936273.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Advani RJ, Bae HR, Bock JB, et al. (1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". J. Biol. Chem. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
• Prekeris R, Klumperman J, Chen YA, Scheller RH (1998). "Syntaxin 13 Mediates Cycling of Plasma Membrane Proteins via Tubulovesicular Recycling Endosomes". J. Cell Biol. 143 (4): 957–71. doi:10.1083/jcb.143.4.957. PMC 2132958. PMID 9817754.
• Steegmaier M, Yang B, Yoo JS, et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
• McBride HM, Rybin V, Murphy C, et al. (1999). "Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13". Cell 98 (3): 377–86. doi:10.1016/S0092-8674(00)81966-2. PMID 10458612.
• Huang L, Kuo YM, Gitschier J (1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nat. Genet. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180.
• Minakami R, Kato A, Sugiyama H (2000). "Interaction of Vesl-1L/Homer 1c with syntaxin 13". Biochem. Biophys. Res. Commun. 272 (2): 466–71. doi:10.1006/bbrc.2000.2777. PMID 10833436.
• Hirling H, Steiner P, Chaperon C, et al. (2000). "Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking". Eur. J. Neurosci. 12 (6): 1913–23. doi:10.1046/j.1460-9568.2000.00076.x. PMID 10886332.
• Steiner P, Sarria JC, Glauser L, et al. (2002). "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD". J. Cell Biol. 157 (7): 1197–209. doi:10.1083/jcb.200202022. PMC 2173541. PMID 12070131.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sun W, Yan Q, Vida TA, Bean AJ (2003). "Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex". J. Cell Biol. 162 (1): 125–37. doi:10.1083/jcb.200302083. PMC 2172712. PMID 12847087.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with Syntaxin 13 and Flotillin-1 and Enhanced Phagocytosis in Tangier Cells". Mol. Biol. Cell 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC 532019. PMID 15469992.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.