STX1B

Syntaxin 1B
Rendering of STX1B from PDB 1hvv​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1hvv​, 1jth​, 1kil​, 1n7s​, 1urq​
Identifiers
Symbols	STX1B ; GEFSP9; STX1B1; STX1B2
External IDs	OMIM: 601485 MGI: 1930705 HomoloGene: 69375 GeneCards: STX1B Gene
Gene ontology Molecular function • SNARE binding • SNAP receptor activity • protein kinase binding • protein domain specific binding Cellular component • nucleus • microtubule organizing center • spindle • cytosol • plasma membrane • synaptic vesicle • endomembrane system • membrane • integral component of membrane • SNARE complex Biological process • positive regulation of neurotransmitter secretion • intracellular protein transport • exocytosis • regulation of gene expression • regulation of synaptic vesicle priming • synaptic vesicle docking • synaptic vesicle fusion to presynaptic membrane • vesicle docking • spontaneous neurotransmitter secretion • positive regulation of excitatory postsynaptic potential Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	112755	56216
Ensembl	ENSG00000099365	ENSMUSG00000030806
UniProt	P61266	P61264
RefSeq (mRNA)	NM_052874	NM_024414
RefSeq (protein)	NP_443106	NP_077725
Location (UCSC)	Chr 16: 30.99 – 31.01 Mb	Chr 7: 127.8 – 127.82 Mb
PubMed search

Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.^[1]

Interactions

STX1B has been shown to interact with UNC13B.^[2]

References

1. "Entrez Gene: STX1B2 syntaxin 1B2".
2. Betz, A; Okamoto M; Benseler F; Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". J. Biol. Chem. (UNITED STATES) 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. ISSN 0021-9258. PMID 8999968.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Li G, Alexander EA, Schwartz JH (2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis.". J. Biol. Chem. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay.". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.
• Nagamatsu S, Nakamichi Y, Watanabe T, et al. (2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules.". J. Cell. Sci. 114 (Pt 1): 219–227. PMID 11112705.
• Betz A, Okamoto M, Benseler F, Brose N (1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.". J. Biol. Chem. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
• Smirnova T, Miniou P, Viegas-Pequignot E, Mallet J (1997). "Assignment of the human syntaxin 1B gene (STX) to chromosome 16p11.2 by fluorescence in situ hybridization.". Genomics 36 (3): 551–3. doi:10.1006/geno.1996.0506. PMID 8884284.
• Smirnova T, Stinnakre J, Mallet J (1993). "Characterization of a presynaptic glutamate receptor.". Science 262 (5132): 430–3. doi:10.1126/science.8105537. PMID 8105537.