COPG

Coatomer protein complex, subunit gamma 1
PDB rendering based on 1pzd.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1R4X​
Identifiers
Symbols	COPG1 ; COPG
External IDs	OMIM: 615525 MGI: 1858696 HomoloGene: 56745 GeneCards: COPG1 Gene
Gene ontology Molecular function • structural molecule activity • protein binding Cellular component • Golgi membrane • cytosol • COPI vesicle coat Biological process • intracellular protein transport • retrograde vesicle-mediated transport, Golgi to ER • COPI coating of Golgi vesicle • establishment of Golgi localization • membrane organization • organelle transport along microtubule Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22820	54161
Ensembl	ENSG00000181789	ENSMUSG00000030058
UniProt	Q9Y678	Q9QZE5
RefSeq (mRNA)	NM_016128	NM_017477
RefSeq (protein)	NP_057212	NP_059505
Location (UCSC)	Chr 3: 129.25 – 129.28 Mb	Chr 6: 87.89 – 87.91 Mb
PubMed search

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene.^[1][2] It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.^[1]

Interactions

COPG has been shown to interact with Dopamine receptor D1,^[3] COPZ1^[1][4] and COPB1.^[1][5]

References

1. Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (February 2001). "Identification and characterization of novel isoforms of COP I subunits". J Biochem 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
2. "Entrez Gene: COPG coatomer protein complex, subunit gamma".
3. Bermak, Jason C; Li Ming; Bullock Clayton; Weingarten Paul; Zhou Qun-Yong (February 2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. (Germany) 81 (2): 77–85. doi:10.1078/0171-9335-00222. ISSN 0171-9335. PMID 11893085.
4. Faulstich, D; Auerbach S; Orci L; Ravazzola M; Wegchingel S; Lottspeich F; Stenbeck G; Harter C; Wieland F T; Tschochner H (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. (UNITED STATES) 135 (1): 53–61. doi:10.1083/jcb.135.1.53. ISSN 0021-9525. PMC 2121028. PMID 8858162.
5. Lowe, M; Kreis T E (November 1996). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. (UNITED STATES) 271 (48): 30725–30. doi:10.1074/jbc.271.48.30725. ISSN 0021-9258. PMID 8940050.

Further reading

• Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor.". J. Biol. Chem. 271 (48): 30725–30. doi:10.1074/jbc.271.48.30725. PMID 8940050.
• Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
• Fischer KD, Helms JB, Zhao L, Wieland FT (2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles.". Methods 20 (4): 455–64. doi:10.1006/meth.2000.0958. PMID 10720466.
• Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Sullivan BM, Harrison-Lavoie KJ, Marshansky V; et al. (2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.". Mol. Biol. Cell 11 (9): 3155–68. doi:10.1091/mbc.11.9.3155. PMC 14982. PMID 10982407.
• Hahn Y, Lee YJ, Yun JH; et al. (2000). "Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution.". FEBS Lett. 482 (1–2): 31–6. doi:10.1016/S0014-5793(00)02033-0. PMID 11018518.
• Paulsson KM, Kleijmeer MJ, Griffith J; et al. (2002). "Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum". J. Biol. Chem. 277 (21): 18266–71. doi:10.1074/jbc.M201388200. PMID 11884415.
• Bermak JC, Li M, Bullock C; et al. (2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. 81 (2): 77–85. doi:10.1078/0171-9335-00222. PMID 11893085.
• Kanzaki M, Watson RT, Hou JC; et al. (2003). "Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes". Mol. Biol. Cell 13 (7): 2334–46. doi:10.1091/mbc.01-10-0490. PMC 117317. PMID 12134073.
• Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rohde HM, Cheong FY, Konrad G; et al. (2004). "The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex". J. Biol. Chem. 278 (52): 52689–99. doi:10.1074/jbc.M307983200. PMID 14527956.
• Watson PJ, Frigerio G, Collins BM; et al. (2004). "Gamma-COP appendage domain - structure and function". Traffic 5 (2): 79–88. doi:10.1111/j.1600-0854.2004.00158.x. PMID 14690497.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.