SYT11

Synaptotagmin XI
Identifiers
Symbols	SYT11 ; SYT12; sytXI
External IDs	OMIM: 608741 MGI: 1859547 HomoloGene: 23120 GeneCards: SYT11 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • calcium-dependent phospholipid binding • syntaxin binding • clathrin binding Cellular component • plasma membrane • integral component of plasma membrane • synaptic vesicle • cell junction • synaptic vesicle membrane Biological process • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of neurotransmitter secretion • calcium ion-dependent exocytosis of neurotransmitter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23208	229521
Ensembl	ENSG00000132718	ENSMUSG00000068923
UniProt	Q9BT88	Q9R0N3
RefSeq (mRNA)	NM_152280	NM_018804
RefSeq (protein)	NP_689493	NP_061274
Location (UCSC)	Chr 1: 155.86 – 155.89 Mb	Chr 3: 88.74 – 88.78 Mb
PubMed search

Synaptotagmin-11 is a protein that in humans is encoded by the SYT11 gene.^[1][2]

Interactions

SYT11 has been shown to interact with Parkin (ligase).^[3]

References

1. Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics 77 (1-2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
2. "Entrez Gene: SYT11 synaptotagmin XI".
3. Huynh, Duong P; Scoles Daniel R; Nguyen Dung; Pulst Stefan M (Oct 2003). "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI". Hum. Mol. Genet. (England) 12 (20): 2587–97. doi:10.1093/hmg/ddg269. ISSN 0964-6906. PMID 12925569.

Further reading

• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huynh DP, Scoles DR, Nguyen D, Pulst SM (2004). "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.". Hum. Mol. Genet. 12 (20): 2587–97. doi:10.1093/hmg/ddg269. PMID 12925569.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Glass AS, Huynh DP, Franck T, et al. (2004). "Screening for mutations in synaptotagmin XI in Parkinson's disease.". J. Neural Transm. Suppl. (68): 21–8. PMID 15354386.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Inoue S, Imamura A, Okazaki Y, et al. (2007). "Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (3): 332–40. doi:10.1002/ajmg.b.30465. PMID 17192956.