SYT2

Synaptotagmin II
Identifiers
Symbols	SYT2 ; CMS7; MYSPC; SytII
External IDs	OMIM: 600104 MGI: 99666 HomoloGene: 22516 GeneCards: SYT2 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • calcium-dependent phospholipid binding • syntaxin binding • clathrin binding Cellular component • plasma membrane • integral component of membrane • cell junction • synaptic vesicle membrane • chromaffin granule membrane • intracellular membrane-bounded organelle Biological process • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis • synaptic vesicle endocytosis • calcium ion-dependent exocytosis of neurotransmitter • positive regulation of dendrite extension Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	127833	20980
Ensembl	ENSG00000143858	ENSMUSG00000026452
UniProt	Q8N9I0	P46097
RefSeq (mRNA)	NM_001136504	NM_009307
RefSeq (protein)	NP_001129976	NP_033333
Location (UCSC)	Chr 1: 202.59 – 202.71 Mb	Chr 1: 134.65 – 134.76 Mb
PubMed search

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.^[1][2]

References

1. Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (Jun 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mamm Genome 6 (3): 212–3. doi:10.1007/BF00293017. PMID 7749232.
2. "Entrez Gene: SYT2 synaptotagmin II".

Further reading

• Fukuda M, Aruga J, Niinobe M, et al. (1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II". J. Biol. Chem. 269 (46): 29206–11. PMID 7961887.
• Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
• Baram D, Adachi R, Medalia O, et al. (1999). "Synaptotagmin II Negatively Regulates Ca2+-triggered Exocytosis of Lysosomes in Mast Cells". J. Exp. Med. 189 (10): 1649–58. doi:10.1084/jem.189.10.1649. PMC 2193646. PMID 10330444.
• Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Kida Y, Sakaguchi M, Fukuda M, et al. (2000). "Membrane Topogenesis of a Type I Signal-Anchor Protein, Mouse Synaptotagmin Ii, on the Endoplasmic Reticulum". J. Cell Biol. 150 (4): 719–30. doi:10.1083/jcb.150.4.719. PMC 2175286. PMID 10952998.
• Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (2001). "Stonin 2: An Adaptor-like Protein That Interacts with Components of the Endocytic Machinery". J. Cell Biol. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094.
• Kida Y, Sakaguchi M, Fukuda M, et al. (2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II". FEBS Lett. 507 (3): 341–5. doi:10.1016/S0014-5793(01)03000-9. PMID 11696368.
• Lindmark IM, Karlsson A, Serrander L, et al. (2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochim. Biophys. Acta 1590 (1–3): 159–66. doi:10.1016/S0167-4889(02)00209-4. PMID 12063179.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rickman C, Archer DA, Meunier FA, et al. (2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate". J. Biol. Chem. 279 (13): 12574–9. doi:10.1074/jbc.M310710200. PMID 14709554.
• Lee BH, Min X, Heise CJ, et al. (2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding". Mol. Cell 15 (5): 741–51. doi:10.1016/j.molcel.2004.07.018. PMID 15350218.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.