STX7

Syntaxin 7
PDB rendering based on 1gl2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1gl2​
Identifiers
Symbol	STX7
External IDs	OMIM: 603217 MGI: 1858210 HomoloGene: 37823 GeneCards: STX7 Gene
Gene ontology Molecular function • SNARE binding • SNAP receptor activity • protein binding • chloride channel inhibitor activity • syntaxin binding Cellular component • immunological synapse • lysosome • lysosomal membrane • endosome • early endosome • late endosome • plasma membrane • endomembrane system • integral component of membrane • endocytic vesicle • SNARE complex • early endosome membrane • vesicle • azurophil granule • intracellular membrane-bounded organelle • perinuclear region of cytoplasm • recycling endosome • extracellular exosome • tertiary granule Biological process • positive regulation of T cell mediated cytotoxicity • intracellular protein transport • vesicle fusion • vesicle docking • organelle localization • organelle assembly • positive regulation of receptor localization to synapse • regulation of protein localization to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8417	53331
Ensembl	ENSG00000079950	ENSMUSG00000019998
UniProt	O15400	Q8BH40
RefSeq (mRNA)	NM_003569	NM_016797
RefSeq (protein)	NP_003560	NP_058077
Location (UCSC)	Chr 6: 132.45 – 132.51 Mb	Chr 10: 24.15 – 24.19 Mb
PubMed search

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.^[1][2]

In melanocytic cells STX7 gene expression may be regulated by MITF.^[3]

Interactions

STX7 has been shown to interact with STX8,^[4] VPS18,^[5] Vesicle-associated membrane protein 8^[4][6] and VPS11.^[5]

References

1. Wang H, Frelin L, Pevsner J (November 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene 199 (1–2): 39–48. doi:10.1016/S0378-1119(97)00343-0. PMID 9358037.
2. "Entrez Gene: STX7 syntaxin 7".
3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
4. Antonin, W; Holroyd C; Fasshauer D; Pabst S; Von Mollard G F; Jahn R (Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. (ENGLAND) 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. ISSN 0261-4189. PMC 305878. PMID 11101518.
5. Kim, B Y; Krämer H; Yamamoto A; Kominami E; Kohsaka S; Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. (United States) 276 (31): 29393–402. doi:10.1074/jbc.M101778200. ISSN 0021-9258. PMID 11382755.
6. Wade, N; Bryant N J; Connolly L M; Simpson R J; Luzio J P; Piper R C; James D E (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. (United States) 276 (23): 19820–7. doi:10.1074/jbc.M010838200. ISSN 0021-9258. PMID 11278762.

Further reading

• Wong SH, Xu Y, Zhang T, Hong W (1998). "Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment". J. Biol. Chem. 273 (1): 375–80. doi:10.1074/jbc.273.1.375. PMID 9417091.
• Steegmaier M, Yang B, Yoo JS, et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
• Prekeris R, Yang B, Oorschot V, et al. (1999). "Differential Roles of Syntaxin 7 and Syntaxin 8 in Endosomal Trafficking". Mol. Biol. Cell 10 (11): 3891–908. doi:10.1091/mbc.10.11.3891. PMC 25687. PMID 10564279.
• Nakamura N, Yamamoto A, Wada Y, Futai M (2000). "Syntaxin 7 mediates endocytic trafficking to late endosomes". J. Biol. Chem. 275 (9): 6523–9. doi:10.1074/jbc.275.9.6523. PMID 10692457.
• Scales SJ, Chen YA, Yoo BY, et al. (2000). "SNAREs contribute to the specificity of membrane fusion". Neuron 26 (2): 457–64. doi:10.1016/S0896-6273(00)81177-0. PMID 10839363.
• Mullock BM, Smith CW, Ihrke G, et al. (2000). "Syntaxin 7 Is Localized to Late Endosome Compartments, Associates with Vamp 8, and Is Required for Late Endosome–Lysosome Fusion". Mol. Biol. Cell 11 (9): 3137–53. doi:10.1091/mbc.11.9.3137. PMC 14981. PMID 10982406.
• Antonin W, Holroyd C, Fasshauer D, et al. (2001). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
• Wade N, Bryant NJ, Connolly LM, et al. (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
• Kim BY, Krämer H, Yamamoto A, et al. (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
• Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Antonin W, Fasshauer D, Becker S, et al. (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. PMID 11786915.
• Antonin W, Dulubova I, Arac D, et al. (2002). "The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly". J. Biol. Chem. 277 (39): 36449–56. doi:10.1074/jbc.M204369200. PMID 12114520.
• Bogdanovic A, Bennett N, Kieffer S, et al. (2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC 1222979. PMID 12175335.
• Collins RF, Schreiber AD, Grinstein S, Trimble WS (2002). "Syntaxins 13 and 7 function at distinct steps during phagocytosis". J. Immunol. 169 (6): 3250–6. doi:10.4049/jimmunol.169.6.3250. PMID 12218144.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell Proteomics 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Suzuki J, Ohnishi H, Wada A, et al. (2003). "Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA". J. Biol. Chem. 278 (28): 25585–90. doi:10.1074/jbc.M212445200. PMID 12730232.