Syntaxin binding protein 3

Syntaxin binding protein 3
PDB rendering based on 2pjx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2pjx​
Identifiers
Symbols	STXBP3 ; MUNC18-3; MUNC18C; PSP; UNC-18C
External IDs	OMIM: 608339 MGI: 107362 HomoloGene: 5260 GeneCards: STXBP3 Gene
Gene ontology Molecular function • protein binding • syntaxin-1 binding • syntaxin binding Cellular component • cytosol • plasma membrane • basolateral plasma membrane • apical plasma membrane • platelet alpha granule • specific granule • extracellular exosome • tertiary granule Biological process • vesicle docking involved in exocytosis • brain development • blood coagulation • glucose transport • protein to membrane docking • insulin secretion • platelet activation • response to insulin • neutrophil degranulation • negative regulation of calcium ion-dependent exocytosis • protein heterooligomerization • membrane organization • platelet aggregation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6814	20912
Ensembl	ENSG00000116266	ENSMUSG00000027882
UniProt	O00186	Q60770
RefSeq (mRNA)	NM_007269	NM_011504
RefSeq (protein)	NP_009200	NP_035634
Location (UCSC)	Chr 1: 108.75 – 108.81 Mb	Chr 3: 108.79 – 108.84 Mb
PubMed search

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.^[1][2]

Interactions

Syntaxin binding protein 3 has been shown to interact with STX2^[3] and STX4.^[3][4]

References

1. Reed GL, Houng AK, Fitzgerald ML (May 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441.
2. "Entrez Gene: STXBP3 syntaxin binding protein 3".
3. Schraw, Todd D; Lemons Paula P; Dean William L; Whiteheart Sidney W (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. (England) 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094.
4. Widberg, Charlotte H; Bryant Nia J; Girotti Milena; Rea Shane; James David E (Sep 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. (United States) 278 (37): 35093–101. doi:10.1074/jbc.M304261200. ISSN 0021-9258. PMID 12832401.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants.". J. Neurosci. 16 (21): 6695–702. PMID 8824310.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex.". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Widberg CH, Bryant NJ, Girotti M, et al. (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.". J. Biol. Chem. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fu J, Naren AP, Gao X, et al. (2005). "Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression.". J. Biol. Chem. 280 (5): 3178–84. doi:10.1074/jbc.M410044200. PMID 15576373.
• Hodgkinson CP, Mander A, Sale GJ (2005). "Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.". Biochem. J. 388 (Pt 3): 785–93. doi:10.1042/BJ20041845. PMC 1183457. PMID 15707389.