DNM3

Dynamin 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3L43​
Identifiers
Symbols	DNM3 ; Dyna III
External IDs	OMIM: 611445 MGI: 1341299 HomoloGene: 22906 GeneCards: DNM3 Gene
EC number	3.6.5.5
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • type 1 metabotropic glutamate receptor binding • type 5 metabotropic glutamate receptor binding • nitric-oxide synthase binding Cellular component • photoreceptor inner segment • mitochondrion • Golgi apparatus • microtubule • postsynaptic density • axon • synaptic cleft • dendritic spine • dendritic spine head • perinuclear region of cytoplasm • extracellular exosome Biological process • endocytosis • synapse assembly • metabolic process • filopodium assembly • positive regulation of filopodium assembly • negative regulation of dendritic spine morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26052	103967
Ensembl	ENSG00000197959	ENSMUSG00000040265
UniProt	Q9UQ16	Q8BZ98
RefSeq (mRNA)	NM_001136127	NM_001038619
RefSeq (protein)	NP_001129599	NP_001033708
Location (UCSC)	Chr 1: 171.84 – 172.42 Mb	Chr 1: 161.98 – 162.48 Mb
PubMed search

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene.^[1][2] The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding.^[3] DNM3 is upregulated in Sézary's syndrome.^[4]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
2. "Entrez Gene: DNM3 dynamin 3".
3. Orth JD, McNiven MA (February 2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
4. Booken N, Gratchev A, Utikal J, Weiss C, Yu X, Qadoumi M, Schmuth M, Sepp N, Nashan D, Rass K, Tüting T, Assaf C, Dippel E, Stadler R, Klemke CD, Goerdt S (February 2008). "Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3". Leukemia 22 (2): 393–9. doi:10.1038/sj.leu.2405044. PMID 18033314.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Sever S (2003). "Dynamin and endocytosis.". Curr. Opin. Cell Biol. 14 (4): 463–7. doi:10.1016/S0955-0674(02)00347-2. PMID 12383797.
• Wiejak J, Wyroba E (2003). "Dynamin: characteristics, mechanism of action and function.". Cell. Mol. Biol. Lett. 7 (4): 1073–80. PMID 12511974.
• Orth JD, McNiven MA (2003). "Dynamin at the actin-membrane interface.". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
• Tu JC, Xiao B, Yuan JP; et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.". Neuron 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Navarro-Lérida I, Martínez Moreno M, Roncal F; et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
• Larsen MR, Graham ME, Robinson PJ, Roepstorff P (2004). "Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III.". Mol. Cell Proteomics 3 (5): 456–65. doi:10.1074/mcp.M300105-MCP200. PMID 14762214.
• Kamioka Y, Fukuhara S, Sawa H; et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis.". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.