GPSM2

G-protein signaling modulator 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3SF4​
Identifiers
Symbols	GPSM2 ; CMCS; DFNB82; LGN; PINS
External IDs	OMIM: 609245 MGI: 1923373 HomoloGene: 56584 GeneCards: GPSM2 Gene
Gene ontology Molecular function • protein binding • GTPase regulator activity • identical protein binding Cellular component • cytoplasm • cell cortex • apical part of cell Biological process • establishment of mitotic spindle orientation • G-protein coupled receptor signaling pathway • regulation of catalytic activity • lung epithelial cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29899	76123
Ensembl	ENSG00000121957	ENSMUSG00000027883
UniProt	P81274	Q8VDU0
RefSeq (mRNA)	NM_013296	NM_029522
RefSeq (protein)	NP_037428	NP_083798
Location (UCSC)	Chr 1: 108.88 – 108.93 Mb	Chr 3: 108.68 – 108.72 Mb
PubMed search

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.^[1][2][3]

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]^[3]

Interactions

GPSM2 has been shown to interact with Nuclear mitotic apparatus protein 1^[4] and GNAI2.^[2][5]

References

1. Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
2. Mochizuki N, Cho G, Wen B, Insel PA (Jan 1997). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene 181 (1-2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305. Check date values in: |year= / |date= mismatch (help)
3. "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)".
4. Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
5. Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.

Further reading

• Du Q, Stukenberg PT, Macara IG (2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
• Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
• Kaushik R, Yu F, Chia W, Yang X, Bahri S (2003). "Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression". Mol. Biol. Cell 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752.
• Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540.
• Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y (2005). "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division". J. Biol. Chem. 280 (8): 6761–5. doi:10.1074/jbc.C400440200. PMID 15632202.
• Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T (2005). "Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population". J. Hypertens. 23 (8): 1497–505. doi:10.1097/01.hjh.0000174606.41651.ae. PMID 16003176.
• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.