GRIP1 (gene)

Glutamate receptor interacting protein 1
PDB rendering based on 1m5z.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2JIL​
Identifiers
Symbols	GRIP1 ; GRIP
External IDs	OMIM: 604597 MGI: 1921303 HomoloGene: 12938 GeneCards: GRIP1 Gene
Gene ontology Molecular function • transcription coactivator activity • protein binding • beta-catenin binding • protein C-terminus binding • receptor signaling complex scaffold activity • glucocorticoid receptor binding • androgen receptor binding Cellular component • endoplasmic reticulum • cytosol • plasma membrane • cytoplasmic membrane-bounded vesicle • cell junction • dendrite • neuron projection • membrane raft • postsynaptic membrane • recycling endosome Biological process • synaptic transmission • protein localization • dendrite development • androgen receptor signaling pathway • intracellular signal transduction • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23426	74053
Ensembl	ENSG00000155974	ENSMUSG00000034813
UniProt	Q9Y3R0	Q925T6
RefSeq (mRNA)	NM_001178074	NM_001277292
RefSeq (protein)	NP_001171545	NP_001264221
Location (UCSC)	Chr 12: 66.35 – 66.8 Mb	Chr 10: 119.45 – 120.09 Mb
PubMed search

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.^[1][2]

Interactions

GRIP1 (gene) has been shown to interact with:

• GRM3,^[3]
• GRIA2,^[3]
• GRIA3,^[3]
• GRIA4,^[3]
• GRIK2,^[3][4] and
• GRIK3.^[5]

References

1. Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (April 1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.
2. "Entrez Gene: GRIP1 glutamate receptor interacting protein 1".
3. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
4. Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron 37 (4): 625–38. doi:10.1016/S0896-6273(02)01191-1. PMC 3314502. PMID 12597860.
5. Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (June 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.

Further reading

• Irvine RA, Ma H, Yu MC, et al. (2000). "Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length.". Hum. Mol. Genet. 9 (2): 267–74. doi:10.1093/hmg/9.2.267. PMID 10607837.
• Teyssier C, Belguise K, Galtier F, Chalbos D (2001). "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.". J. Biol. Chem. 276 (39): 36361–9. doi:10.1074/jbc.M101806200. PMID 11477071.
• Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.
• Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
• Braithwaite SP, Xia H, Malenka RC (2002). "Differential roles for NSF and GRIP/ABP in AMPA receptor cycling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7096–101. doi:10.1073/pnas.102156099. PMC 124534. PMID 12011465.
• Kotaja N, Karvonen U, Jänne OA, Palvimo JJ (2002). "The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1". J. Biol. Chem. 277 (33): 30283–8. doi:10.1074/jbc.M204768200. PMID 12060666.
• Min G, Kim H, Bae Y, et al. (2002). "Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators". J. Biol. Chem. 277 (37): 34626–33. doi:10.1074/jbc.M205239200. PMID 12114525.
• Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell. Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
• Charych EI, Yu W, Li R, et al. (2004). "A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain". J. Biol. Chem. 279 (37): 38978–90. doi:10.1074/jbc.M405786200. PMID 15226318.
• Sugatani J, Nishitani S, Yamakawa K, et al. (2005). "Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1". Mol. Pharmacol. 67 (3): 845–55. doi:10.1124/mol.104.007161. PMID 15557560.
• Lin DY, Fang HI, Ma AH, et al. (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMC 533990. PMID 15572661.
• Yang CK, Kim JH, Li H, Stallcup MR (2006). "Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97. doi:10.1074/jbc.M510403200. PMC 1626527. PMID 16344550.
• Liu PY, Hsieh TY, Chou WY, Huang SM (2006). "Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains". FEBS J. 273 (10): 2172–83. doi:10.1111/j.1742-4658.2006.05231.x. PMID 16649994.
• Tsai SJ, Liou YJ, Liao DL, et al. (2007). "No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (3): 752–5. doi:10.1016/j.pnpbp.2007.01.015. PMID 17303296.