Gammaretrovirus core encapsidation signal

Gammaretrovirus core encapsidation signal
Predicted secondary structure and sequence conservation of Gammaretro_CES
Identifiers
Symbol Gammaretro_CES
Rfam RF00374
Other data
RNA type Cis-reg
Domain(s) Eukaryota; Viruses
SO 0000233
A 3D representation of a Gammaretrovirus core encapsidation signal. This is a view of the NMR structure for the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus.[1]
A 3D representation of a Gammaretrovirus. This structure shows the packaging of the dimeric genome of Moloney murine leukaemia virus, of which the encapsidation signal forms a part.[2]

The Gammaretrovirus core encapsidation signal is an RNA element known to be essential for stable dimerisation and efficient genome packaging during virus assembly.[1] Dimerisation of the viral RNA genomes is proposed to act as an RNA conformational switch which exposes conserved UCUG elements and enables efficient genome encapsidation.[2] The structure of this element is composed of three stem-loops. Two of the stem-loops called SL-C and SL-D form a single co-axial extend helix.

See also

References

  1. 1 2 D'Souza V, Dey A, Habib D, Summers MF (2004). "NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus". J Mol Biol 337 (2): 427–442. doi:10.1016/j.jmb.2004.01.037. PMID 15003457.
  2. 1 2 D'Souza V, Summers MF (2004). "Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus". Nature 431 (7008): 586–590. doi:10.1038/nature02944. PMID 15457265.

External links


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