Genipin

Genipin

Names
IUPAC name Methyl (1R,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
Identifiers
CAS Number	6902-77-8
ChEMBL	ChEMBL459016
ChemSpider	390864
Jmol interactive 3D	Image
KEGG	C09780
PubChem	442424
InChI InChI=1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1 Key: AZKVWQKMDGGDSV-BCMRRPTOSA-N InChI=1/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1 Key: AZKVWQKMDGGDSV-BCMRRPTOBC
SMILES O=C(OC)\C1=C\O[C@@H](O)[C@@H]2\C(=C/C[C@H]12)CO
Properties
Chemical formula	C11H14O5
Molar mass	226.226 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Genipin is a chemical compound found in gardenia fruit extract. It is an aglycone derived from an iridoid glycoside called geniposide present in fruit of Gardenia jasminoides.

Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking.^[1] It has a low acute toxicity, with LD₅₀ i.v. 382 mg/kg in mice, therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking reagents.^[1] Furthermore, genipin can be used as a regulating agent for drug delivery, as the raw material for gardenia blue pigment preparation, and as the intermediate for alkaloid syntheses.^[2]

In vitro experiments have shown that genipin blocks the action of the enzyme uncoupling protein 2.^[3]

References

1. CBC Genipin
2. Introduction of genipin
3. Zhang, CY; Parton, LE; Ye, CP; Krauss, S; Shen, R; Lin, CT; Porco Jr, JA; Lowell, BB (2006). "Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets". Cell Metabolism 3 (6): 417–27. doi:10.1016/j.cmet.2006.04.010. PMID 16753577.