Geranoyl-CoA carboxylase

The 3 substrates of this enzyme are ATP, geranoyl-CoA, and HCO3-, whereas its 3 products are ADP, phosphate, and 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon–carbon bonds. The systematic name of this enzyme class is geranoyl-CoA:carbon-dioxide ligase (ADP-forming). Other names in common use include geranoyl coenzyme A carboxylase, and geranyl-CoA carboxylase. It employs one cofactor, biotin.

References

Seubert W, Fass E and Remberger U (1963). "Untersuchungen uber den bakteriellen Abbau von Isoprenoiden. III Reinigung und Eigenschaften der Geranylcarboxylase". Biochem. Z. 338: 265–275.

Ligases: carbon-carbon ligases (EC 6.4)

Biotin dependent carboxylation	Pyruvate carboxylase Acetyl-CoA carboxylase Propionyl-CoA carboxylase Methylcrotonyl-CoA carboxylase

Other	Polyketide synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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