Geranyl-pyrophosphate—olivetolic acid geranyltransferase

Geranyl-pyrophosphate—olivetolic acid geranyltransferase (EC 2.5.1.102, GOT) is an enzyme with systematic name geranyl-diphosphate:olivetolate geranyltransferase.^[1] This enzyme catalyses the following chemical reaction

geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate

\rightleftharpoons

diphosphate + cannabigerolate

Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa.

References

↑ Fellermeier, M. and Zenk, M.H. (1998). "Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol". FEBS Lett 427: 283–285. doi:10.1016/S0014-5793(98)00450-5. PMID 9607329.

External links

Geranyl-pyrophosphate---olivetolic acid geranyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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