Geranyl diphosphate 2-C-methyltransferase

Geranyl diphosphate 2-C-methyltransferase (EC 2.1.1.255, SCO7701, GPP methyltransferase, GPPMT, 2-methyl-GPP synthase, MGPPS, geranyl pyrophosphate methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + geranyl diphosphate

\rightleftharpoons

S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate

This enzyme takes part in synthesis of 2-methylisoborneol.

References

↑ Wang, C.M. and Cane, D.E. (2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". J. Am. Chem. Soc. 130: 8908–8909. doi:10.1021/ja803639g. PMID 18563898.
↑ Ariyawutthiphan, O., Ose, T., Tsuda, M., Gao, Y., Yao, M., Minami, A., Oikawa, H. and Tanaka, I. (2011). "Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67: 417–420. doi:10.1107/s1744309110051523. PMID 21393856.
↑ Komatsu, M., Tsuda, M., Omura, S., Oikawa, H. and Ikeda, H. (2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proc. Natl. Acad. Sci. USA 105: 7422–7427. doi:10.1073/pnas.0802312105. PMID 18492804.
↑ Giglio, S., Chou, W.K., Ikeda, H., Cane, D.E. and Monis, P.T. (2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environ. Sci. Technol. 45: 992–998. doi:10.1021/es102992p. PMID 21174459.

External links

Geranyl diphosphate 2-C-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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