Geranylgeranyl diphosphate reductase

Geranylgeranyl diphosphate reductase (EC 1.3.1.83, geranylgeranyl reductase, CHL P) is an enzyme with systematic name geranylgeranyl-diphosphate:NADP⁺ oxidoreductase.^[1]^[2]^[3] This enzyme catalises the following chemical reaction

phytyl diphosphate + 3 NADP⁺

\rightleftharpoons

geranylgeranyl diphosphate + 3 NADPH + 3 H⁺

This enzyme also acts on geranylgeranyl-chlorophyll a.

References

↑ Soll, J., Schultz, G., Rudiger, W. and Benz, J. (1983). "Hydrogenation of geranylgeraniol : two pathways exist in spinach chloroplasts". Plant Physiol. 71 (4): 849–854. doi:10.1104/pp.71.4.849. PMC 1066133. PMID 16662918.
↑ Tanaka, R., Oster, U., Kruse, E., Rudiger, W. and Grimm, B. (1999). "Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductas". Plant Physiol. 120 (3): 695–704. doi:10.1104/pp.120.3.695. PMC 59307. PMID 10398704.
↑ Keller, Y., Bouvier, F., d'Harlingue, A. and Camara, B. (1998). "Metabolic compartmentation of plastid prenyllipid biosynthesis—evidence for the involvement of a multifunctional geranylgeranyl reductase". Eur. J. Biochem. 251 (1-2): 413–417. doi:10.1046/j.1432-1327.1998.2510413.x. PMID 9492312.

External links

Geranylgeranyl diphosphate reductase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article is issued from Wikipedia - version of the Wednesday, March 30, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.